Differentiation-associated alteration in sensitivity to apoptosis induced by (-)-epigallocatechin-3-O-gallate in HL-60 cells

被引：12

作者：

Okada, Norihisa ^{[1
,2
]}

Tanabe, Hiroki ^{[1
,2
]}

Tazoe, Hideaki ^{[1
,2
]}

Ishigami, Yoko ^{[1
,2
]}

Fukutomi, Ryuuta ^{[3
]}

Yasui, Kensuke ^{[4
]}

Isemura, Mamoru ^{[1
,2
]}

机构：

[1] Univ Shizuoka, Grad Sch Nutr & Environm Sci, Shizuoka 4228526, Japan

[2] Univ Shizuoka, Global COE, Shizuoka 4228526, Japan

[3] Nisshin Seifun Grp Inc, Fujimino, Saitama 3568511, Japan

[4] Nisshin Pharma Inc, Fujimino, Saitama 3568511, Japan

来源：

BIOMEDICAL RESEARCH-TOKYO | 2009年 / 30卷 / 04期

关键词：

LEUKEMIA-CELLS; GREEN TEA; GENE-EXPRESSION; 1,25-DIHYDROXYVITAMIN D-3; DNA FRAGMENTATION; DEATH APOPTOSIS; TUMOR-CELLS; INDUCTION; GALLATE; CARCINOGENESIS;

D O I：

10.2220/biomedres.30.201

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Green tea and its constituent (-)-epigallocatechin-3-O-gallate (EGCG) are known to have apoptosis-inducing activity on tumor cells Including human leukemia HL-60 cells, providing an explanation for their anti-cancer effects. In the present study, we compared the sensitivity of undifferentiated cells and differentiated HL-60 cells with normal-like phenotypic characters. HL-60 cells treated with three differentiating agents were found to be resistant to EGCG-mediated apoptosis as compared with undifferentiated cells. Gene and protein expression of 67 kDa laminin receptor was down-regulated in differentiated HL-60 cells, suggesting its contribution to the difference in sensitivity in view of the fact that the receptor is a target of EGCG's action to induce apoptosis. The finding supports the view that EGCG induces apoptosis preferentially in cancer cells as compared with normal counterparts.

引用

页码：201 / 206

页数：6

共 28 条

[1] EXPRESSION OF LEUKOCYTE DIFFERENTIATION ANTIGENS DURING THE DIFFERENTIATION OF HL-60 CELLS INDUCED BY 1,25-DIHYDROXYVITAMIN D-3 - COMPARISON WITH THE MATURATION OF NORMAL MONOCYTIC AND GRANULOCYTIC BONE-MARROW CELLS
BRACKMAN, D
LUNDJOHANSEN, F
AARSKOG, D
[J]. JOURNAL OF LEUKOCYTE BIOLOGY, 1995, 58 (05) : 547 - 555
[2] Gene expression spectra in human leukemia HL-60 cells treated with EGCG
Cao, J
Ren, LL
Liu, JW
Li, Y
Qu, HY
[J]. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2004, 556 (1-2) : 193 - 200
[3] Green tea epigallocatechin gallate shows a pronounced growth inhibitory effect on cancerous cells but not on their normal counterparts
Chen, ZP
Schell, JB
Ho, CT
Chen, KY
[J]. CANCER LETTERS, 1998, 129 (02) : 173 - 179
[4] Laminin-induced signaling in tumor cells
Givant-Horwitz, V
Davidson, B
Reich, R
[J]. CANCER LETTERS, 2005, 223 (01) : 1 - 10
[5] GUNJI H, 1991, CANCER RES, V51, P741
[6] Inhibition of prostate carcinogenesis in TRAMP mice by oral infusion of green tea polyphenols
Gupta, S
Hastak, K
Ahmad, N
Lewin, JS
Mukhtar, H
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (18) : 10350 - 10355
[7] Hibasami H, 1996, ANTICANCER RES, V16, P1943
[8] EFFECTS OF CATECHINS ON THE MOUSE LUNG-CARCINOMA CELL-ADHESION TO THE ENDOTHELIAL-CELLS
ISEMURA, M
SUZUKI, Y
SATOH, K
NARUMI, K
MOTOMIYA, M
[J]. CELL BIOLOGY INTERNATIONAL, 1993, 17 (06) : 559 - 564
[9] Induction of apoptosis in human leukemia cells by black tea and its polyphenol theaflavin
Kundu, T
Dey, S
Roy, M
Siddiqi, M
Bhattacharya, RK
[J]. CANCER LETTERS, 2005, 230 (01) : 111 - 121
[10] MIYAURA C, 1985, CANCER RES, V45, P4244

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