Brain circuits involved in emotional learning in antisocial behavior and social phobia in humans

被引：260

作者：

Veit, R

Flor, H

Erb, M

Hermann, C

Lotze, M

Grodd, W

Birbaumer, N

机构：

[1] Univ Tubingen, Inst Med Psychol & Behav Neurobiol, D-72074 Tubingen, Germany

[2] Univ Heidelberg, Dept Clin & Cognit Neurosci, Cent Inst Mental Hlth, D-68159 Mannheim, Germany

[3] Univ Tubingen, Dept Neuroradiol, Sect Exptl Resonance Imaging, CNS, D-74070 Tubingen, Germany

[4] Univ Padua, Dept Gen Psychol, I-35131 Padua, Italy

来源：

NEUROSCIENCE LETTERS | 2002年 / 328卷 / 03期

关键词：

emotional learning; Pavlovian conditioning; psychopathy; social phobia; functional magnetic resonance imaging; skin conductance;

D O I：

10.1016/S0304-3940(02)00519-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

While psychopaths (PP) lack anticipatory fear, social phobics (SP) are characterized by excessive fear. Criminal PP, SP and healthy controls (HC) participated in differential aversive delay conditioning with neutral faces as conditioned (CS) and painful pressure as unconditioned stimuli. Functional magnetic resonance imaging revealed differential activation in the limbic-prefrontal circuit (orbitofrontal cortex, insula, anterior cingulate, amygdala) in the HC. By contrast, the PP displayed brief amygdala, but no further brain activation. The SIP showed increased activity to the faces in the amygdala and orbitofrontal cortex already during habituation. Thus, a hypoactive frontolimbic circuit may represent the neural correlate of psychopathic behavior, whereas an overactive frontolimbic system may underly social fear. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：233 / 236

页数：4

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