Cytotoxic Triterpenoids from the Stems of Microtropis japonica

被引:32
作者
Chen, I-Hsiao [1 ]
Lu, Mei-Chin [1 ]
Du, Ying-Chi [1 ]
Yen, Ming-Hong [1 ]
Wu, Chin-Chung [1 ]
Chen, Yung-Husan [1 ]
Hung, Chih-Sheng [1 ]
Chen, Shu-Li [1 ]
Chang, Fang-Rong [1 ,2 ,3 ]
Wu, Yang-Chang [1 ,2 ,3 ]
机构
[1] Kaohsiung Med Univ, Sch Pharm, Grad Inst Nat Prod, Kaohsiung 807, Taiwan
[2] Natl Sun Yat Sen Univ, Kaohsiung Med Univ, Joint Res Ctr, Kaohsiung 804, Taiwan
[3] Kaohsiung Med Univ, Ctr Excellence Environm Med, Kaohsiung 807, Taiwan
来源
JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 07期
关键词
DIHYDROAGAROFURANOID SESQUITERPENE; URSOLIC ACID; ANTICANCER ACTIVITY; INHIBITORS; CELLS; CONSTITUENTS; EXTRACTS; ACETYLATION; ANTIOXIDANT; FOKIENENSIS;
D O I
10.1021/np800694b
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Bioassay-guided fractionation of a methanol extract obtained from stems of Microtropis japonica led to the isolation of six new ursane-type triterpenoids (1-6) and a new 2,3-seco-oleanane-type triterpenoid (7), together with seven known compounds. The structures of the new compounds were elucidated using spectroscopic data analysis. Among the known compounds isolated, the main component, 8 (ursolic acid), was active for HL60 cells, and its effects on histone hyperacetylation and the inhibition of histone deacetylase (HDAC) activity were investigated.
引用
收藏
页码:1231 / 1236
页数:6
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