Cytotoxic Triterpenoids from the Stems of Microtropis japonica

被引：32

作者：

Chen, I-Hsiao ^{[1
]}

Lu, Mei-Chin ^{[1
]}

Du, Ying-Chi ^{[1
]}

Yen, Ming-Hong ^{[1
]}

Wu, Chin-Chung ^{[1
]}

Chen, Yung-Husan ^{[1
]}

Hung, Chih-Sheng ^{[1
]}

Chen, Shu-Li ^{[1
]}

Chang, Fang-Rong ^{[1
,2
,3
]}

Wu, Yang-Chang ^{[1
,2
,3
]}

机构：

[1] Kaohsiung Med Univ, Sch Pharm, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Natl Sun Yat Sen Univ, Kaohsiung Med Univ, Joint Res Ctr, Kaohsiung 804, Taiwan

[3] Kaohsiung Med Univ, Ctr Excellence Environm Med, Kaohsiung 807, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 07期

关键词：

DIHYDROAGAROFURANOID SESQUITERPENE; URSOLIC ACID; ANTICANCER ACTIVITY; INHIBITORS; CELLS; CONSTITUENTS; EXTRACTS; ACETYLATION; ANTIOXIDANT; FOKIENENSIS;

D O I：

10.1021/np800694b

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Bioassay-guided fractionation of a methanol extract obtained from stems of Microtropis japonica led to the isolation of six new ursane-type triterpenoids (1-6) and a new 2,3-seco-oleanane-type triterpenoid (7), together with seven known compounds. The structures of the new compounds were elucidated using spectroscopic data analysis. Among the known compounds isolated, the main component, 8 (ursolic acid), was active for HL60 cells, and its effects on histone hyperacetylation and the inhibition of histone deacetylase (HDAC) activity were investigated.

引用

页码：1231 / 1236

页数：6

共 34 条

[1] Cytotoxic triterpenoids from the leaves of Microtropis fokienensis [J].

Chen, I-Hsiao ;

Chang, Fang-Rong ;

Wu, Chin-Chung ;

Chen, Shu-Li ;

Hsieh, Pei-Wen ;

Yen, Hsin-Fu ;

Du, Ying-Chi ;

Wu, Yang-Chang .

JOURNAL OF NATURAL PRODUCTS, 2006, 69 (11) :1543-1546

[2] Dihydroagarofuranoid sesquiterpenes, a lignan derivative, a benzenoid, and antitubercular constituents from the stem of Microtropis japonica [J].

Chen, Jih-Jung ;

Yang, Chang-Syun ;

Peng, Chien-Fang ;

Chen, Ih-Sheng ;

Miaw, Chang-Ling .

JOURNAL OF NATURAL PRODUCTS, 2008, 71 (06) :1016-1021

[3] A new dihydroagarofuranoid sesquiterpene and antituberculosis constituents from the root of Microtropis japonica [J].

Chou, Tsung-Hsien ;

Chen, Ih-Sheng ;

Peng, Chien-Fang ;

Sung, Ping-Jyun ;

Chen, Jih-Jung .

CHEMISTRY & BIODIVERSITY, 2008, 5 (07) :1412-1418

[4] A new dihydroagarofuranoid sesquiterpene from Microtropis fokienensis with antituberculosis activity [J].

Chou, Tsung-Hsien ;

Chen, Ih-Sheng ;

Sung, Ping-Jyun ;

Peng, Chien-Fang ;

Shieh, Po-Chuen ;

Chen, Jih-Jung .

CHEMISTRY & BIODIVERSITY, 2007, 4 (07) :1594-1600

[5] Antiulcerogenic activity of fractions and 3,15-dioxo-21α-hydroxy friedelane isolated from Maytenus robusta (Celastraceae) [J].

de Andrade, Sergio Faloni ;

Comunello, Eros ;

Noldin, Vania Floriani ;

Delle Monache, Franco ;

Cechinel Filho, Valdir ;

Niero, Rivaldo .

ARCHIVES OF PHARMACAL RESEARCH, 2008, 31 (01) :41-46

[6] Immunosuppressive terpenoids from extracts of Tripterygium wilfordii [J].

Duan, HQ ;

Takaishi, Y ;

Momota, H ;

Ohmoto, Y ;

Taki, T ;

Tori, M ;

Takaoka, S ;

Jia, YF ;

Li, D .

TETRAHEDRON, 2001, 57 (40) :8413-8424

[7] Antioxidant, anti-inflammatory and anticancer activities of methanolic extracts from Ledum groenlandicum Retzius [J].

Dufour, Dominic ;

Pichette, Andre ;

Mshvildadze, Vakhtang ;

Bradette-Hebert, Marie-Eve ;

Lavoie, Serge ;

Longtin, Angelique ;

Laprise, Catherine ;

Legault, Jean .

JOURNAL OF ETHNOPHARMACOLOGY, 2007, 111 (01) :22-28

[8] A TRITERPENE FROM RUBUS-PINFAENSIS [J].

DURHAM, DG ;

LIU, XJ ;

RICHARDS, RME .

PHYTOCHEMISTRY, 1994, 36 (06) :1469-1472

[9]

Dwarakanath BS, 2008, INDIAN J MED RES, V128, P13

[10] DNA polymerase β lyase inhibitors from Maytenus putterlickoides [J].

Feng, XZ ;

Gao, ZJ ;

Li, SS ;

Jones, SH ;

Hecht, SM .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (10) :1744-1747

← 1 2 3 4 →