Future perspective for potential H elicobacter pylori eradication therapies

被引：61

作者：

Debraekeleer, Ayla ^{[1
,2
]}

Remaut, Han ^{[1
,2
]}

机构：

[1] VIB, VIB Ctr Struct Biol, Dept Struct & Mol Microbiol, Pl Laan 2, B-1050 Brussels, Belgium

[2] Vrije Univ Brussel, Dept Struct Biol Brussels, Pl Laan 2, B-1050 Brussels, Belgium

来源：

FUTURE MICROBIOLOGY | 2018年 / 13卷 / 06期

关键词：

antibacterial; antibiotic resistance; antivirulence therapy; gastric cancer; Helicobacter pylori; peptic ulcer; ANTI-HELICOBACTER-PYLORI; PROTON-PUMP INHIBITOR; SELECTIVE ANTIBACTERIAL AGENTS; CARBONIC-ANHYDRASE INHIBITORS; IN-VITRO; GLUTAMATE RACEMASE; MEDICINAL-PLANTS; ANTIMICROBIAL PROPERTIES; COMPETITIVE INHIBITORS; BIOLOGICAL EVALUATION;

D O I：

10.2217/fmb-2017-0115

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Helicobacter pylori infection of the human stomach causes chronic inflammation and forms a major risk factor for the development of peptic ulcer disease and gastric cancer. Current standard eradication therapies use an acid-suppressing drug and two antibiotics, now frequently supplemented with bismuth. Declining eradication efficiencies, off-target effects of lengthy broad-spectrum antibiotic treatments and the desire of a more systematic eradication in asymptomatic H. pylori carriers to suppress gastric cancer incidence spur a search for an effective vaccine and alternative therapeutic options. Here, we review the current progress in the field, with an emphasis on narrow-spectrum or nonantibiotic therapeutics. [GRAPHICS] .

引用

页码：671 / 687

页数：17

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