Targeted delivery of extracellular vesicles in heart injury

被引：73
作者：
Chen, Peier [1 ,2 ,3 ,4 ]
Wang, Ling [5 ]
Fan, Xianglin [1 ,2 ,3 ,4 ]
Ning, Xiaodong [1 ,2 ,3 ,4 ]
Yu, Bin [1 ,2 ,3 ,4 ]
Ou, Caiwen [1 ,2 ,3 ,4 ]
Chen, Minsheng [1 ,2 ,3 ,4 ]
机构：
[1] Southern Med Univ, Zhujiang Hosp, Lab Heart Ctr, Guangzhou, Peoples R China
[2] Southern Med Univ, Zhujiang Hosp, Dept Cardiol, Guangzhou, Peoples R China
[3] Guangdong Prov Biomed Engn Technol Res Ctr Cardio, Guangzhou, Peoples R China
[4] Lab Heart Ctr, Sino Japanese Cooperat Platform Translat Res Hear, Guangzhou, Peoples R China
[5] Southern Med Univ, Biomat Res Ctr, Sch Biomed Engn, Guangzhou 510515, Peoples R China
来源：
THERANOSTICS | 2021年 / 11卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Extracellular Vesicles; Biogenesis; Heart Injury; Challenges; Targeted Delivery; CELL-DERIVED EXOSOMES; ACUTE MYOCARDIAL-INFARCTION; STEM-CELLS; PHYSICOCHEMICAL PROPERTIES; RETICULOCYTE MATURATION; CARDIAC REPAIR; GROWTH-FACTOR; IN-VITRO; HYDROGEL; BIOMARKERS;
D O I：
10.7150/thno.51571
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Extracellular vesicles (EVs) are nanoscale extracellular vesicles derived from endocytosis that are crucial to intercellular communication. EVs possess natural biocompatibility and stability that allow them to cross biological membranes and that protect them from degradation. Recent studies have shown that EVs-mediated crosstalk between different cell types in the heart could play important roles in the maintenance of cardiac homeostasis and the pathogenesis of heart diseases. In particular, EVs secreted by different types of stem cells exhibit cardioprotective effects. However, numerous studies have shown that intravenously injected EVs are quickly cleared by macrophages of the mononuclear phagocyte system (MPS) and preferentially accumulate in MPS organs such as the liver, spleen, and lung. In this review, we discuss exosome biogenesis, the role of EVs in heart diseases, and challenges in delivering EVs to the heart. Furthermore, we extensively discuss the targeted delivery of EVs for treating ischemic heart disease. These understandings will aid in the development of effective treatment strategies for heart diseases.
引用
收藏
页码：2263 / 2277
页数：15
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