Synthesis and Antimicrobial Activities of 5-Arylidene-thiazolidine-2,4-dione Derivatives

被引：26

作者：

da Silva, Ivanildo Mangueira ^{[1
]}

da Silva Filho, Joao ^{[2
]}

da Silva Santiago, Priscila Brandao Gomes ^{[1
]}

do Egito, Micalyne Soares ^{[1
]}

de Souza, Carlos Andre ^{[2
]}

Gouveia, Frederico Leite ^{[1
]}

Ximenes, Rafael Matos ^{[2
]}

da Fonseca Ribeiro de Sena, Kesia Xisto ^{[2
]}

de Faria, Antonio Rodolfo ^{[1
]}

Brondani, Dalci Jose ^{[1
]}

Cavalcanti de Albuquerque, Julianna Ferreira ^{[1
,2
]}

机构：

[1] Univ Fed Pernambuco, Dept Pharm, BR-50670901 Recife, PE, Brazil

[2] Univ Fed Pernambuco, Dept Antibiot, BR-50670901 Recife, PE, Brazil

来源：

BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷

关键词：

INHIBITORS; 4-THIAZOLIDINONES; THIAZOLIDINONES; RHODANINE; DESIGN;

D O I：

10.1155/2014/316082

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Antibiotic resistance is considered one of the world's major public health concerns. The main cause of bacterial resistance is the improper and repeated use of antibiotics. To alleviate this problem, new chemical substances against microorganisms are being synthesized and tested. Thiazolidines are compounds having many pharmacological activities including antimicrobial activities. For this purpose some thiazolidine derivatives substituted at position 5 in the thiazolidine nucleus were synthesized and tested against several microorganisms. Using a disc diffusion method, antimicrobial activity was verified against Gram-positive, Gram-negative, and alcohol acid resistant bacteria and yeast. The minimum inhibition concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined. All derivatives showed antimicrobial activity mainly against Gram-positive bacteria, with MIC values ranging from 2 to 16 mu g/mL.

引用

页数：8

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