Associations between Vitamin D-Binding Protein (DBP) Gene Polymorphism (TAAA)n and Development of Osteoporosis in the Volga-Ural Region of Russia

被引：6

作者：

Khusainova, R. I. ^{[1
,2
]}

Seleznyova, L. I. ^{[1
]}

Mal'tsev, A. V. ^{[2
]}

Shakirova, R. Ya. ^{[1
]}

Nurlygayanov, R. Z. ^{[1
]}

Nadyrshina, D. D. ^{[2
]}

Khusnutdinova, E. K. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, Ural Res Ctr, Inst Biochem & Genet, Ufa 450001, Russia

[2] Bashkir State Univ, Ufa 450074, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 157卷 / 02期

关键词：

osteoporosis; bone fractures; vitamin D-binding protein gene; BONE-MINERAL DENSITY; RISK;

D O I：

10.1007/s10517-014-2538-5

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Study of DBP gene (TAAA) (n) polymorphism in women of postmenopausal age revealed a significantly lower incidence of DBP (*) 10 allele and a higher incidence of DBP (*) 11 allele in Russian women with bone fractures in comparison with the relevant controls (chi(2) = 4.47, p = 0.034 and chi(2) = 4.28, p = 0.038, respectively). Allele DBP (*) 11 is a high risk marker (OR = 1.93; 95%CI 1.06-3.48), while allele DBP(*)10 a marker of low risk of bone fractures (OR = 0.59; 95%CI 0.37-0.94). A trend to a reduction of mineral density of the femoral neck and of the lumbar vertebrae in women with DBP (*) 10 (*) 8 genotype of DBP gene polymorphic locus (TAAA) (n) in comparison with DBP (*) 10 (*) 10 and DBP (*) 10 (*) 11 genotype carriers is traced.

引用

页码：253 / 257

页数：5

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