Body mass index trajectories from adolescent to young adult for incident high blood pressure and high plasma glucose

Objectives To explore the association between sex-specific adiposity trajectories among Adolescents to early adulthood with incident high blood pressure (HBP) and high plasma glucose (HPG). Methods We studied body mass index (BMI) trajectories among1 159 (male = 517) and 664 (male = 263) Iranian adolescents, aged 12-20 years, for incident HPG and HBP, respectively. Latent Class Growth Mixture Modeling (LCGMM) on longitudinal data was used to determine sex-specific and distinct BMI trajectories. Logistic regressions were applied to estimate the relationship between latent class membership with HBP and HPG, considering normal trajectory as the reference. Results For both HBP and HPG, LCGMM determined two and three distinct BMI trajectories in males and females, respectively. During a follow-up of 12 Years 104 (male = 62) and 111 (male = 59) cases of HPG and HBP were found, respectively. Among females, faster BMI increases (i.e. overweight to early obese trajectory) but not overweight (i.e. those with BMI = 27.3 kg/m(2) at baseline) trajectories increased the risk of HPG by adjusted odds ratios (ORs), 2.74 (1.10-5.80) and 0.79 (0.22-2.82), respectively; regarding HBP, the corresponding value for overweight to late obese trajectory was 3.72 (1.37-11.02). Among males, for HBP, the overweight trajectory increased the risk [2.09 (1.04-4.03)]; however, for incident HPG, none of the trajectories showed significant risk. Conclusions Among females, trend of increasing BMI parallel with age can be a better predictor for risk of developing HPG and HBP than those with higher BMI at baseline.