The Collaborative Ocular Tuberculosis Study (COTS)-1: A Multinational Review of 447 Patients with Tubercular Intermediate Uveitis and Panuveitis

被引：8

作者：

Agrawal, Rupesh ^{[1
,2
,3
,4
]}

Betzler, Bjorn Kaijun ^{[1
,4
]}

Testi, Ilaria ^{[3
]}

Mahajan, Sarakshi ^{[5
]}

Agarwal, Aniruddha ^{[6
]}

Gunasekeran, Dinesh Visva ^{[2
]}

Raje, Dhananjay ^{[7
]}

Aggarwal, Kanika ^{[6
]}

Murthy, Somasheila, I ^{[8
]}

Westcott, Mark ^{[3
]}

Chee, Soon-Phaik ^{[1
,4
,9
,10
]}

McCluskey, Peter ^{[11
]}

Ho, Su Ling ^{[2
]}

Teoh, Stephen ^{[2
]}

Cimino, Luca ^{[12
]}

Biswas, Jyotirmay ^{[13
]}

Narain, Shishir ^{[14
]}

Agarwal, Manisha ^{[15
]}

Mahendradas, Padmamalini ^{[16
]}

Khairallah, Moncef ^{[17
]}

Jones, Nicholas ^{[18
]}

Tugal-Tutkun, Ilknur ^{[19
]}

Babu, Kalpana ^{[20
,21
]}

Basu, Soumayava ^{[22
]}

Carreno, Ester ^{[23
]}

Lee, Richard ^{[3
]}

Al-Dhibi, Hassan ^{[24
]}

Bodaghi, Bahram ^{[25
]}

Invernizzi, Alessandro ^{[26
]}

Goldstein, Debra A. ^{[27
]}

Barisani-Asenbauer, Talin ^{[28
]}

Gonzalez-Lopez, Julio J. ^{[29
]}

Androudi, Sofia ^{[30
]}

Bansal, Reema ^{[6
]}

Moharana, Bruttendu ^{[6
]}

Esposti, Simona Degli ^{[3
]}

Tasiopoulou, Anastasia ^{[3
]}

Nadarajah, Sengal ^{[3
]}

Agarwal, Mamta ^{[13
]}

Abraham, Sharanaya ^{[13
]}

Vala, Ruchi ^{[16
]}

Singh, Ramandeep ^{[6
]}

Sharma, Aman ^{[31
]}

Sharma, Kusum ^{[32
]}

Zierhut, Manfred ^{[33
]}

Kon, Onn Min ^{[34
]}

Cunningham, Emmett T. ^{[35
]}

Kempen, John H. ^{[36
,37
,38
]}

Nguyen, Quan Dong ^{[39
]}

Pavesio, Carlos ^{[3
]}

机构：

[1] Tan Tock Seng Hosp, Natl Healthcare Grp, Eye Inst, Singapore, Singapore

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore

[3] Moorfields Eye Hosp, NHS Fdn Trust, London, England

[4] Singapore Eye Res Inst, Ocular Infect & Antimicrobials, Singapore, Singapore

[5] St Joseph Mercy Hosp, Dept Med, Pontiac, MI USA

[6] Postgrad Inst Med Educ & Res PGIMER, Adv Eye Ctr, Chandigarh, India

[7] MDS Bioanalyt, Nagpur, Maharashtra, India

[8] LV Prasad Eye Inst, Tej Kohli Cornea Inst, Hyderabad, India

[9] Singapore Natl Eye Ctr, Singapore, Singapore

[10] Duke NUS Med Sch, Dept Ophthalmol & Visual Sci, Acad Clin Program, Singapore, Singapore

[11] Univ Sydney, Save Sight Inst, Cent Clin Sch, Dept Clin Ophthalmol & Eye Hlth, Sydney, NSW, Australia

[12] Azienda USL IRCCS, Ocular Immunol Unit, Reggio Emilia, Italy

[13] Sankara Nethralaya, Dept Ophthalmol, Chennai, Tamil Nadu, India

[14] Shroff Eye Ctr, Dept Ophthalmol, New Delhi, India

[15] Dr Shroffs Char Eye Hosp Daryaganj, Dept Ophthalmol, New Delhi, India

[16] Narayana Nethralaya, Dept Uveitis & Ocular Immunol, Bangalore, Karnataka, India

[17] Univ Monastir, Fattouma Bourguiba Univ Hosp, Dept Ophthalmol, Fac Med, Monastir, Tunisia

[18] Univ Manchester, Dept Ophthalmol, Manchester, Lancs, England

[19] Istanbul Univ, Dept Ophthalmol, Istanbul Fac Med, Istanbul, Turkey

[20] Vittala Int Inst Ophthalmol, Prabha Eye Clin, Bangalore, Karnataka, India

[21] Vittala Int Inst Ophthalmol, Res Ctr, Bangalore, Karnataka, India

[22] LV Prasad Eye Inst, Dept Ophthalmol, Bhubaneswar, India

[23] Hosp Univ Fdn Jimenez Diaz, Madrid, Spain

[24] King Khalid Eye Specialist Hosp, Dept Ophthalmol, Riyadh, Saudi Arabia

[25] Sorbonne Univ, Dept Ophthalmol, DHU SightRestore, Paris, France

[26] Univ Milan, Dept Biomed & Clin Sci L Sacco, Eye Clin, Luigi Sacco Hosp, Milan, Italy

[27] Northwestern Univ, Dept Ophthalmol, Feinberg Sch Med, Chicago, IL 60611 USA

[28] Med Univ Vienna, Ctr Ocular Inflammat & Infect OCUVAC, Laura Bassi Ctr Expertise, Ctr Pathophysiol Infectiol & Immunol, Vienna, Austria

[29] Ramon Y Cajal Univ Hosp, Dept Ophthalmol, Madrid, Spain

[30] Univ Thessaly, Dept Ophthalmol, Thessaly, Greece

[31] PGIMER, Dept Rheumatol, Chandigarh, India

[32] PGIMER, Dept Microbiol, Chandigarh, India

[33] Univ Tubingen, Dept Ophthalmol, Ctr Ophthalmol, Tubingen, Germany

[34] Imperial Coll Healthcare NHS Trust, Chest & Allergy Clin, St Marys Hosp, London, England

[35] UCSF Sch Med, Francis I Proctor Fdn, San Francisco, CA USA

[36] Harvard Med Sch, Dept Ophthalmol, Massachusetts Eye & Ear, Boston, MA 02115 USA

[37] MyungSung Christian Med Ctr, MCM Eye Unit, Addis Ababa, Ethiopia

[38] MyungSung Med Sch, Addis Ababa, Ethiopia

[39] Stanford Sch Med, Byers Eye Inst, Palo Alto, CA USA

来源：

OCULAR IMMUNOLOGY AND INFLAMMATION | 2020年 / 28卷

基金：

英国医学研究理事会;

关键词：

Anti-tubercular therapy; collaborative ocular tuberculosis study (COTS); ocular tuberculosis; tubercular intermediate uveitis; tubercular panuveitis; tubercular uveitis; uveitis; THERAPY; POPULATION; DIAGNOSIS; ASSAY;

D O I：

10.1080/09273948.2020.1808226

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: Tubercular intermediate uveitis (TIU) and panuveitis (TBP) are difficult to manage because of limitations in diagnostic tools and lack of evidence-based treatment guidelines. The Collaborative Ocular Tuberculosis Study (COTS) analyzed treatment regimens and therapeutic outcomes in patients with TIU and TBP. Methods: Multicentre retrospective analysis. Results A total of 138 TIU and 309 TBP patients were included. A total of 382 subjects received antitubercular therapy (ATT) (n = 382/447; 85.4%) and 382 received corticosteroids (n = 382/447; 85.4%). Treatment failure was observed in 78 individuals (n = 78/447; 17.4%), occurring less frequently in patients receiving ATT (n = 66/382; 17.2%) compared to those who did not (n = 12/65; 18.5%). The study did not show any statistically significant therapeutic effect of ATT in patients with TIU and TBP. Conclusion Taking into account the limitations of the retrospective, non-randomized study design, resultant reliance on reported data records, and unequal size of the samples, the current study cannot provide conclusive evidence on the therapeutic benefit of ATT in TIU and TBP.

引用

页码：27 / 37

页数：11

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