Liver X receptor modulators: Effects on lipid metabolism and potential use in the treatment of atherosclerosis

被引：79
作者：
Fievet, C. [1 ,2 ,3 ]
Staels, B. [1 ,2 ,3 ]
机构：
[1] Inst Pasteur, INSERM, U545, F-59019 Lille, France
[2] Univ Lille 2, Fac Sci Pharmaceut & Biol, F-59006 Lille, France
[3] Fac Med, F-59006 Lille, France
来源：
BIOCHEMICAL PHARMACOLOGY | 2009年 / 77卷 / 08期
关键词：
LXRs; Cholesterol homeostasis; Liver steatosis; LXR ligands; Atherosclerosis; PHOSPHOLIPID TRANSFER PROTEIN; DENSITY-LIPOPROTEIN RECEPTOR; CELLULAR CHOLESTEROL EFFLUX; ELEMENT-BINDING PROTEIN; LXR-ALPHA; NUCLEAR RECEPTOR; OXYSTEROL RECEPTOR; HDL CHOLESTEROL; GENE-EXPRESSION; PHARMACOLOGICAL ACTIVATION;
D O I：
10.1016/j.bcp.2008.11.026
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Liver X receptors (LXRs) are nuclear receptors that play a crucial role in regulating the expression of genes involved in lipid metabolism. Ligand activation of LXRs improves cholesterol homeostasis via multiple coordinated effects, and this function is likely to explain in part the protective effects of LXR activation on atherosclerosis reported in animal models. However, LXR activation may also induce undesirable side effects, such as lipogenesis and hypertriglyceridemia. This review discusses the potential to develop LXR modulators as therapeutic agents for atherosclerosis. (C) 2008 Elsevier Inc. All rights reserved.
引用
收藏
页码：1316 / 1327
页数：12
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