Synthesis and in vivo Anti-inflammatory Evaluation of Piperazine Derivatives Containing 1,4-Benzodioxan Moiety

被引：8

作者：

Liu, Zhi-Ping ^{[1
]}

Gong, Chang-Da ^{[2
]}

Xie, Long-Yan ^{[2
]}

Du, Xiu-Li ^{[2
]}

Li, Yang ^{[2
]}

Qin, Jie ^{[2
]}

机构：

[1] Pingdingshan Univ, Sch Med, Pingdingshan 467000, Peoples R China

[2] Shandong Univ Technol, Sch Life Sci, Zibo 255049, Peoples R China

来源：

ACTA CHIMICA SLOVENICA | 2019年 / 66卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Piperazine; 1,4-benzodioxan; crystal structure; anti-inflammatory activity; SELECTIVE COX-2 INHIBITORS; BIOLOGICAL EVALUATION; MOLECULAR DOCKING; DESIGN; ANALOGS;

D O I：

10.17344/acsi.2018.4887

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Six piperazine derivatives 6a-f containing 1,4-benzodioxan moiety have been synthesized and characterized by H-1 NMR, ESI-MS and elemental analysis. The structure of 6d was further confirmed by single crystal X-ray diffraction. All these novel compounds were screened for their in vivo anti-inflammatory activity employing classical para-xylene-induced mice ear-swelling model. The results revealed that most of the target compounds showed significant anti-inflammatory activities, especially compound 6a with ortho-substituted methoxy group on the phenylpiperazine ring exhibited the best activity among the designed compounds.

引用

页码：421 / 426

页数：6

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