Mechanical Stimulation of Mesenchymal Stem Cells for Tissue Engineering

被引:0
作者
Kim, Jang-Ho [1 ]
Cho, Chong-Su [6 ]
Choung, Yun-Hoon [7 ]
Lim, Ki-Taek [1 ]
Son, Hyun-Mok [1 ]
Seonwoo, Hoon [1 ]
Baik, Soo-Jung [1 ]
Jeon, Soung-Hoo [3 ,4 ,5 ]
Park, Joo-Young [3 ,4 ,5 ]
Choung, Pill-Hoon [3 ,4 ,5 ]
Chung, Jong-Hoon [1 ,2 ]
机构
[1] Seoul Natl Univ, Dept Biosyst Biomater Sci Egn, Seoul 151921, South Korea
[2] Seoul Natl Univ, Res Inst Agr & Life Sci, Seoul 151921, South Korea
[3] Seoul Natl Univ, Dept Oral & Maxillofacial Surg, Seoul 151921, South Korea
[4] Seoul Natl Univ, Dent Res Inst, Sch Dent, Seoul 151921, South Korea
[5] Seoul Natl Univ, Sch Dent, Tooth Bioeng Natl Res Lab BK21, Seoul 151921, South Korea
[6] Seoul Natl Univ, Dept Agr Biotech, Seoul 151921, South Korea
[7] Ajou Univ, Sch Med, Dept Otolaryngol, Suwon 443721, South Korea
关键词
Mechanical stimulation; mesenchymal stem cells; tissue engineering; FULL-THICKNESS DEFECTS; ARTICULAR-CARTILAGE; IN-VITRO; REGENERATIVE MEDICINE; PROGENITOR CELLS; MARROW; STRAIN; DIFFERENTIATION; CHONDROGENESIS; ENVIRONMENT;
D O I
暂无
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Tissue engineering is a rapidly growing field that utilizes cell/scaffolds constructs with chemical signaling molecules as potential therapeutic products for tissue regeneration. Mesenchymal stem cells(MSCs) provide excellent novel strategies for tissue engineering application. Recently, it has been recognized that understanding mechanical stimulation is an important key to the development of efficient and controllable methods as well as chemical signaling for differentiation of MSCs and tissue engineering application. Especially, a number of studies indicated that the mechanical stimuli can enhance the synergy effects for differentiation of MSCs and tissue formation or regeneration. In this review, we introduced the various mechanical stimuli techniques, the effects of mechanical stimuli to MSCs, and tissue engineering applications. Furthermore, we discussed the further research directions of MSCs and mechanical stimuli based on this review for tissue engineering.
引用
收藏
页码:199 / 206
页数:8
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