Epigenetic regulation of adipogenesis by histone-modifying enzymes

被引：16
作者：
Macchia, Paolo Emidio [1 ]
Nettore, Immacolata Cristina [1 ]
Franchini, Fabiana [1 ]
Santana-Viera, Laura [2 ]
Ungaro, Paola [2 ]
机构：
[1] Univ Naples Federico II, Dept Clin Med & Surg, I-80131 Naples, Italy
[2] CNR, Inst Expt Endocrinol & Oncol Gaetano Salvatore, I-80145 Naples, Italy
来源：
EPIGENOMICS | 2021年 / 13卷 / 03期
关键词：
adipogenesis; brown adipose tissue; epigenetics; histone modifications; obesity; white adipose tissue; PROMOTES ADIPOCYTE DIFFERENTIATION; ADIPOSE-TISSUE DEVELOPMENT; STEM-CELL; TRANSCRIPTIONAL CONTROL; GENE-EXPRESSION; CHROMATIN; METHYLATION; ACTIVATION; ENHANCER; THERMOGENESIS;
D O I：
10.2217/epi-2020-0304
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Many studies investigating the transcriptional control of adipogenesis have been published so far; recently the research is focusing on the role of epigenetic mechanisms in regulating the process of adipocyte development. Histone-modifying enzymes and the histone tails post-transcriptional modifications catalyzed by them, are fundamentally involved in the epigenetic regulation of adipogenesis. In our review, we will discuss recent advances in epigenomic regulation of adipogenesis with a focus on histone-modifying enzymes implicated in the various phases of adipocytes differentiation process from mesenchymal stem cells to mature adipocytes. Understanding adipogenesis, may provide new ways to treat obesity and related metabolic diseases.
引用
收藏
页码：235 / 251
页数：17
相关论文
共 98 条
  • [1] Emerging Roles of JmjC Domain-Containing Proteins
    Accari, Sandra L.
    Fisher, Paul R.
    [J]. INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 319, 2015, 319 : 165 - 220
  • [2] Adipogenesis: A Complex Interplay of Multiple Molecular Determinants and Pathways
    Ambele, Melvin A.
    Dhanraj, Priyanka
    Giles, Rachel
    Pepper, Michael S.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (12) : 1 - 27
  • [3] Structure and mechanism of lysine-specific demethylase enzymes
    Anand, Ruchi
    Marmorstein, Ronen
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (49) : 35425 - 35429
  • [4] PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B
    Baba, Atsushi
    Ohtake, Fumiaki
    Okuno, Yosuke
    Yokota, Kenichi
    Okada, Maiko
    Imai, Yuuki
    Ni, Min
    Meyer, Clifford A.
    Igarashi, Katsuhide
    Kanno, Jun
    Brown, Myles
    Kato, Shigeaki
    [J]. NATURE CELL BIOLOGY, 2011, 13 (06) : 668 - U101
  • [5] Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells
    Bäckesjö, CM
    Li, Y
    Lindgren, U
    Haldosén, LA
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2006, 21 (07) : 993 - 1002
  • [6] Adherence to the Mediterranean Diet and Circulating Levels of Sirtuin 4 in Obese Patients: A Novel Association
    Barrea, Luigi
    Tarantino, Giovanni
    Di Somma, Carolina
    Muscogiuri, Giovanna
    Macchia, Paolo Emidio
    Falco, Andrea
    Colao, Annamaria
    Savastano, Silvia
    [J]. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017, 2017
  • [7] High-resolution profiling of histone methylations in the human genome
    Barski, Artern
    Cuddapah, Suresh
    Cui, Kairong
    Roh, Tae-Young
    Schones, Dustin E.
    Wang, Zhibin
    Wei, Gang
    Chepelev, Iouri
    Zhao, Keji
    [J]. CELL, 2007, 129 (04) : 823 - 837
  • [8] Arginine Methylation: The Coming of Age
    Blanc, Romeo S.
    Richard, Stephane
    [J]. MOLECULAR CELL, 2017, 65 (01) : 8 - 24
  • [9] BET bromodomain proteins regulate enhancer function during adipogenesis
    Brown, Jonathan D.
    Feldman, Zachary B.
    Doherty, Sean P.
    Reyes, Jaime M.
    Rahl, Peter B.
    Lin, Charles Y.
    Sheng, Quanhu
    Duan, Qiong
    Federation, Alexander J.
    Kung, Andrew L.
    Haldar, Saptarsi M.
    Young, Richard A.
    Plutzky, Jorge
    Bradner, James E.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2018, 115 (09) : 2144 - 2149
  • [10] Modification of Enhancer Chromatin: What, How, and Why?
    Calo, Eliezer
    Wysocka, Joanna
    [J]. MOLECULAR CELL, 2013, 49 (05) : 825 - 837
12345678910