Epigenetic regulation of adipogenesis by histone-modifying enzymes

被引：16

作者：

Macchia, Paolo Emidio ^{[1
]}

Nettore, Immacolata Cristina ^{[1
]}

Franchini, Fabiana ^{[1
]}

Santana-Viera, Laura ^{[2
]}

Ungaro, Paola ^{[2
]}

机构：

[1] Univ Naples Federico II, Dept Clin Med & Surg, I-80131 Naples, Italy

[2] CNR, Inst Expt Endocrinol & Oncol Gaetano Salvatore, I-80145 Naples, Italy

来源：

EPIGENOMICS | 2021年 / 13卷 / 03期

关键词：

adipogenesis; brown adipose tissue; epigenetics; histone modifications; obesity; white adipose tissue; PROMOTES ADIPOCYTE DIFFERENTIATION; ADIPOSE-TISSUE DEVELOPMENT; STEM-CELL; TRANSCRIPTIONAL CONTROL; GENE-EXPRESSION; CHROMATIN; METHYLATION; ACTIVATION; ENHANCER; THERMOGENESIS;

D O I：

10.2217/epi-2020-0304

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Many studies investigating the transcriptional control of adipogenesis have been published so far; recently the research is focusing on the role of epigenetic mechanisms in regulating the process of adipocyte development. Histone-modifying enzymes and the histone tails post-transcriptional modifications catalyzed by them, are fundamentally involved in the epigenetic regulation of adipogenesis. In our review, we will discuss recent advances in epigenomic regulation of adipogenesis with a focus on histone-modifying enzymes implicated in the various phases of adipocytes differentiation process from mesenchymal stem cells to mature adipocytes. Understanding adipogenesis, may provide new ways to treat obesity and related metabolic diseases.

引用

页码：235 / 251

页数：17

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