Preliminary evaluation of the potential of 99mTc carbonyl-DTPA-Rituximab as a tracer for sentinel lymph node detection

被引：3

作者：

Kameswaran, Mythili ^{[1
]}

Subramanian, Suresh ^{[1
]}

Pandey, Usha ^{[1
]}

Samuel, Grace ^{[1
]}

机构：

[1] Bhabha Atom Res Ctr, Isotope Prod & Applicat Div, Bombay 400085, Maharashtra, India

来源：

APPLIED RADIATION AND ISOTOPES | 2016年 / 107卷

关键词：

Rituximab; Breast lymphoma; Sentinel lymph node; Technetium radiopharmaceuticals; PRIMARY BREAST LYMPHOMA; BIFUNCTIONAL LIGAND; BIOPSY; RADIOPHARMACEUTICALS; BIOMOLECULES; TRIAL;

D O I：

10.1016/j.apradiso.2015.10.025

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Preliminary work with Tc-99m carbonyl-DTPA-Rituximab was attempted to test its feasibility as a sentinel lymph node (SLN) tracer for patients with breast cancer. Tc-99m labeling of DTPA-Rituximab conjugate was carried out via Tc-99m carbonyl synthon which exhibited >95% radiochemical purity and good in vitro stability. In vitro studies of Tc-99m carbonyl-DTPA-Rituximab in normal and malignant B cells showed higher binding in malignant cells. In vivo distribution of Tc-99m carbonyl-DTPA-Rituximab in Wistar rat footpad model indicated good retention by B-cells present in the sentinel lymph node. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：195 / 198

页数：4

共 50 条

[1] 99mTc carbonyl DTPA-Rituximab: Preparation and preliminary bioevaluation
Pandey, Usha
Kameswaran, Mythili
Sarma, Haladhar Dev
Samuel, Grace
APPLIED RADIATION AND ISOTOPES, 2014, 86 : 52 - 56
[2] The efficacy of 99mTc-rituximab as a tracer for sentinel lymph node biopsy in cutaneous melanoma patients
Liu, Jiayong
Tan, Zhichao
Xue, Ruifeng
Fan, Zhengfu
Bai, Chujie
Li, Shu
Gao, Tian
Zhang, Lu
Fang, Zhiwei
Si, Lu
ANNALS OF TRANSLATIONAL MEDICINE, 2022, 10 (02)
[3] Subareolar injection of 99mTc facilitates sentinel lymph node identification
Tuttle, TM
Colbert, M
Christensen, R
Ose, KJ
Jones, T
Wetherille, R
Friedman, J
Swenson, K
McMasters, KM
ANNALS OF SURGICAL ONCOLOGY, 2002, 9 (01) : 77 - 81
[4] Sentinel lymph node detection in early cervical cancer with combination 99mTc phytate and patent blue
Niikura, H
Okamura, C
Akahira, J
Takano, T
Ito, K
Okamura, K
Yaegashi, N
GYNECOLOGIC ONCOLOGY, 2004, 94 (02) : 528 - 532
[5] Clinical Evaluation of 99mTc-Rituximab for Sentinel Lymph Node Mapping in Breast Cancer Patients
Li, Nan
Wang, Xuejuan
Lin, Baohe
Zhu, Hua
Liu, Cheng
Xu, Xiaobao
Zhang, Yan
Zhai, Shizhen
OuYang, Tao
Li, Jinfeng
Yang, Zhi
JOURNAL OF NUCLEAR MEDICINE, 2016, 57 (08) : 1214 - 1220
[6] The Preliminary Analysis of Sentinel Lymph Node Biopsy Guided by 99mTc-Rituximab in Patients with Breast Cancer
Xu, Yijin
Zhang, Ying
Chen, Wen Xin
Lin, Zhiyi
JOURNAL OF NUCLEAR MEDICINE, 2019, 60
[7] Sentinel lymph node detection in oral cancer: a head to head comparison between [99mTc]Tc-Tilmanocept and [99mTc]Tc-Nanocoll
Mahieu, R.
den Toom, I. J.
van Rooij, R.
van Es, R. J. J.
Hobbelink, M. G.
Krijger, G. C.
Tijink, B. M.
de Keizer, B.
de Bree, R.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2020, 47 (SUPPL 1) : S234 - S234
[8] Preliminary evaluation of the hybrid tracer Indocyanine Green (ICG)-99mTc-nanocolloid for sentinel lymph node biopsy in bladder cancer
Rietbergen, D.
van Gennep, E.
KleinJan, G.
Donswijk, M.
van Rijn, B.
Olmos, R. Valdes
van der Poel, H.
van Leeuwen, F.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2021, 48 (SUPPL 1) : S165 - S165
[9] Dose-dependent biodistribution of [99mTc]DTPA-mannosyl-dextran for breast cancer sentinel lymph node mapping
Ellner, SJ
Hoh, CK
Vera, DR
Darrah, DD
Schulteis, G
Wallace, AM
NUCLEAR MEDICINE AND BIOLOGY, 2003, 30 (08) : 805 - 810
[10] Comparison of [99mTc]Tc-tilmanocept with [99mTc]Tc-sulphur colloids and [99mTc]Tc-albumin colloids for sentinel lymph node detection in patients with cutaneous malignancies of the head
Mark Ooms
Dirk von Mallek
Hans-Jürgen Kaiser
Frank Hölzle
Felix M. Mottaghy
Ali Modabber
European Journal of Nuclear Medicine and Molecular Imaging, 2023, 50 : 870 - 880

← 1 2 3 4 5 →