New markers in Parkinson's disease

被引:22
作者
Bougea, Anastasia [1 ,2 ]
机构
[1] Natl & Kapodistrian Univ Athens, Aeginit Hosp, Dept Neurol & Movement Disorders 1, Neurochem Lab,Med Sch, Athens, Greece
[2] Acad Athens, Biomed Res Fdn, Ctr Basic Res, Neurosci Lab, Athens, Greece
来源
ADVANCES IN CLINICAL CHEMISTRY, VOL 96 | 2020年 / 96卷
关键词
FLUID ALPHA-SYNUCLEIN; MILD COGNITIVE IMPAIRMENT; SERUM URIC-ACID; CEREBROSPINAL-FLUID; MOTOR PROGRESSION; DIFFERENTIAL-DIAGNOSIS; CLINICAL-DIAGNOSIS; NATURAL-HISTORY; CSF BIOMARKERS; DECLINE;
D O I
10.1016/bs.acc.2019.12.001
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Parkinson's disease (PD) is a chronic, debilitating neurodegenerative disorder characterized clinically by a variety of progressive motor and nonmotor symptoms. Currently, there is a dearth of diagnostic tools available to predict, diagnose or mitigate disease risk or progression, leading to a challenging dilemma within the healthcare management system. The search for a reliable biomarker for PD that reflects underlying pathology is a high priority in PD research. Currently, there is no reliable single biomarker predictive of risk for motor and cognitive decline, and there have been few longitudinal studies of temporal progression. A combination of multiple biomarkers might facilitate earlier diagnosis and more accurate prognosis in PD. In this review, we focus on the recent developments of serial biomarkers for PD from a variety of clinical, biochemical, genetic and neuroimaging perspectives.
引用
收藏
页码:137 / 178
页数:42
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