New markers in Parkinson's disease

被引：21

作者：

Bougea, Anastasia ^{[1
,2
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Aeginit Hosp, Dept Neurol & Movement Disorders 1, Neurochem Lab,Med Sch, Athens, Greece

[2] Acad Athens, Biomed Res Fdn, Ctr Basic Res, Neurosci Lab, Athens, Greece

来源：

ADVANCES IN CLINICAL CHEMISTRY, VOL 96 | 2020年 / 96卷

关键词：

FLUID ALPHA-SYNUCLEIN; MILD COGNITIVE IMPAIRMENT; SERUM URIC-ACID; CEREBROSPINAL-FLUID; MOTOR PROGRESSION; DIFFERENTIAL-DIAGNOSIS; CLINICAL-DIAGNOSIS; NATURAL-HISTORY; CSF BIOMARKERS; DECLINE;

D O I：

10.1016/bs.acc.2019.12.001

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Parkinson's disease (PD) is a chronic, debilitating neurodegenerative disorder characterized clinically by a variety of progressive motor and nonmotor symptoms. Currently, there is a dearth of diagnostic tools available to predict, diagnose or mitigate disease risk or progression, leading to a challenging dilemma within the healthcare management system. The search for a reliable biomarker for PD that reflects underlying pathology is a high priority in PD research. Currently, there is no reliable single biomarker predictive of risk for motor and cognitive decline, and there have been few longitudinal studies of temporal progression. A combination of multiple biomarkers might facilitate earlier diagnosis and more accurate prognosis in PD. In this review, we focus on the recent developments of serial biomarkers for PD from a variety of clinical, biochemical, genetic and neuroimaging perspectives.

引用

页码：137 / 178

页数：42

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