New markers in Parkinson's disease

被引：21

作者：

Bougea, Anastasia ^{[1
,2
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Aeginit Hosp, Dept Neurol & Movement Disorders 1, Neurochem Lab,Med Sch, Athens, Greece

[2] Acad Athens, Biomed Res Fdn, Ctr Basic Res, Neurosci Lab, Athens, Greece

来源：

ADVANCES IN CLINICAL CHEMISTRY, VOL 96 | 2020年 / 96卷

关键词：

FLUID ALPHA-SYNUCLEIN; MILD COGNITIVE IMPAIRMENT; SERUM URIC-ACID; CEREBROSPINAL-FLUID; MOTOR PROGRESSION; DIFFERENTIAL-DIAGNOSIS; CLINICAL-DIAGNOSIS; NATURAL-HISTORY; CSF BIOMARKERS; DECLINE;

D O I：

10.1016/bs.acc.2019.12.001

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Parkinson's disease (PD) is a chronic, debilitating neurodegenerative disorder characterized clinically by a variety of progressive motor and nonmotor symptoms. Currently, there is a dearth of diagnostic tools available to predict, diagnose or mitigate disease risk or progression, leading to a challenging dilemma within the healthcare management system. The search for a reliable biomarker for PD that reflects underlying pathology is a high priority in PD research. Currently, there is no reliable single biomarker predictive of risk for motor and cognitive decline, and there have been few longitudinal studies of temporal progression. A combination of multiple biomarkers might facilitate earlier diagnosis and more accurate prognosis in PD. In this review, we focus on the recent developments of serial biomarkers for PD from a variety of clinical, biochemical, genetic and neuroimaging perspectives.

引用

页码：137 / 178

页数：42

共 143 条

[1] Saliva alpha-Synuclein and A High Extinction Coefficient Protein: A Novel Approach in Assessment Biomarkers of Parkinson's Disease [J].

Al-Nimer, Marwan S. M. ;

Mshatat, Sabah F. ;

Abdulla, Hajer I. .

NORTH AMERICAN JOURNAL OF MEDICAL SCIENCES, 2014, 6 (12) :633-637

[2] Progression of motor impairment and disability in Parkinson disease - A population-based study [J].

Alves, G ;

Wentzel-Larsen, T ;

Aarsland, D ;

Larsen, JP .

NEUROLOGY, 2005, 65 (09) :1436-1441

[3] Network modulation in the treatment of Parkinson's disease [J].

Asanuma, Kotaro ;

Tang, Chengke ;

Ma, Yilong ;

Dhawan, Vijay ;

Mattis, Paul ;

Edwards, Christine ;

Kaplitt, Michael G. ;

Feigin, Andrew ;

Eidelberg, David .

BRAIN, 2006, 129 :2667-2678

[4] Urate as a Predictor of the Rate of Clinical Decline in Parkinson Disease [J].

Ascherio, Alberto ;

LeWitt, Peter A. ;

Xu, Kui ;

Eberly, Shirley ;

Watts, Arthur ;

Matson, Wayne R. ;

Marras, Connie ;

Kieburtz, Karl ;

Rudolph, Alice ;

Bogdanov, Mikhail B. ;

Schwid, Steven R. ;

Tennis, Marsha ;

Tanner, Caroline M. ;

Beal, M. Flint ;

Lang, Anthony E. ;

Oakes, David ;

Fahn, Stanley ;

Shoulson, Ira ;

Schwarzschild, Michael A. .

ARCHIVES OF NEUROLOGY, 2009, 66 (12) :1460-1468

[5] Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework [J].

Atkinson, AJ ;

Colburn, WA ;

DeGruttola, VG ;

DeMets, DL ;

Downing, GJ ;

Hoth, DF ;

Oates, JA ;

Peck, CC ;

Schooley, RT ;

Spilker, BA ;

Woodcock, J ;

Zeger, SL .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (03) :89-95

[6] Longitudinal study of cognitive and cerebral metabolic changes in Parkinson's disease [J].

Baba, Toru ;

Hosokai, Yoshiyuki ;

Nishio, Yoshiyuki ;

Kikuchi, Akio ;

Hirayama, Kazumi ;

Suzuki, Kyoko ;

Hasegawa, Takafumi ;

Aoki, Masashi ;

Takeda, Atsushi ;

Mori, Etsuro .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2017, 372 :288-293

[7] Cerebrospinal Fluid Patterns and the Risk of Future Dementia in Early, Incident Parkinson Disease [J].

Backstrom, David C. ;

Domellof, Magdalena Eriksson ;

Linder, Jan ;

Olsson, Bob ;

Ohrfelt, Annika ;

Trupp, Miles ;

Zetterberg, Henrik ;

Blennow, Kaj ;

Forsgren, Lars .

JAMA NEUROLOGY, 2015, 72 (10) :1175-1182

[8] Red blood cells are the major source of alpha-synuclein in blood [J].

Barbour, Robin ;

Kling, Kristin ;

Anderson, John P. ;

Banducci, Kelly ;

Cole, Tracy ;

Diep, Linnea ;

Fox, Michael ;

Goldstein, Jason M. ;

Soriano, Ferdie ;

Seubert, Peter ;

Chilcote, Tarnie J. .

NEURODEGENERATIVE DISEASES, 2008, 5 (02) :55-59

[9] Alpha-synuclein oligomers: a new hope [J].

Bengoa-Vergniory, Nora ;

Roberts, Rosalind F. ;

Wade-Martins, Richard ;

Alegre-Abarrategui, Javier .

ACTA NEUROPATHOLOGICA, 2017, 134 (06) :819-838

[10] Time to redefine PD? Introductory statement of the MDS Task Force on the definition of Parkinson's disease [J].

Berg, Daniela ;

Postuma, Ronald B. ;

Bloem, Bastiaan ;

Chan, Piu ;

Dubois, Bruno ;

Gasser, Thomas ;

Goetz, Christopher G. ;

Halliday, Glenda M. ;

Hardy, John ;

Lang, Anthony E. ;

Litvan, Irene ;

Marek, Kenneth ;

Obeso, Jose ;

Oertel, Wolfgang ;

Olanow, C. Warren ;

Poewe, Werner ;

Stern, Matthew ;

Deuschl, Guenther .

MOVEMENT DISORDERS, 2014, 29 (04) :454-462

← 1 2 3 4 5 6 7 8 9 10 →