Highly regioselective catalytic oxidative coupling reactions: Synthetic and mechanistic investigations

被引：327
作者：
Hull, Kami L. [1 ]
Lanni, Erica L. [1 ]
Sanford, Melanie S. [1 ]
机构：
[1] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2006年 / 128卷 / 43期
关键词：
D O I：
10.1021/ja065718e
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly efficient and regioselective Pd-catalyzed method for the oxidative coupling of arylpyridine derivatives is reported. Remarkably, the reactions proceed at room temperature and are compatible with diverse functionalities, including aryl halides and thiophenes. Mechanistic studies suggest that these transformations proceed via a previously unprecedented mechanism involving two different pyridine-directed C-H activation reactions-one at a PdII center and one at PdIV. Copyright © 2006 American Chemical Society.
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收藏
页码：14047 / 14049
页数：3
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