The paper presents experimental investigations into electric discharge grinding (EDG) and ultrasonic vibration-assisted electric discharge grinding (UVAEDG) of Inconel 601. The process parameters selected for both processes were duty cycle, discharge current, pulse on time, grinding wheel speed, work speed, and speed ratio to study their influence on responses like surface roughness (R-a) and material removal rate (MRR). It was found that duty cycle, wheel speed, work speed, discharge current, speed ratio, and pulse duration significantly influenced MRR and R-a. It was inferred that MRR increased with increase in duty cycle, wheel speed, current, work speed, and pulse duration in both EDG and UVAEDG processes. It was also inferred that R-a increased with rise in duty factor, pulse on time, and discharge current in EDG and UVAEDG processes.