Extracts and fractions of Croton L. (Euphorbiaceae) species with antimicrobial activity and antioxidant potential

被引：9

作者：

Rocha, Andre R. F. da S. ^{[1
,7
]}

Sousa, Herbert G. ^{[2
]}

do Vale Junior, Erasmo P. ^{[2
]}

de Lima, Francisca L. ^{[2
]}

Costa, Anabela S. G. ^{[3
]}

de Araujo, Alyne R. ^{[4
]}

Leite, Jose Roberto S. A. ^{[5
,7
]}

Martins, Francielle A. ^{[2
]}

Oliveira, M. Beatriz P. P. ^{[3
]}

Placido, Alexandra ^{[6
,7
]}

Filho, Francisco S. S. ^{[2
]}

Lago, Eliana C. ^{[1
]}

机构：

[1] Univ Estadual Maranhao, Dept Hlth Sci, UEMA, BR-65604380 Caxias, Maranhao, Brazil

[2] Univ Estadual Piaui, Ctr Nat Sci, UESPI, BR-64002150 Teresina, PI, Brazil

[3] Univ Porto, Fac Pharm, Dept Chem Sci, FFUP,LAQV REQUIMTE, P-4050313 Porto, Portugal

[4] Fed Univ Delta Parnaiba, Biotechnol & Biodivers Ctr Res, Biotec, UFDPar, BR-64202020 Parnaiba, PI, Brazil

[5] Univ Brasilia, Ctr Res Appl Morphol & Immunol, NuPMIA, UnB, BR-70910900 Brasilia, DF, Brazil

[6] Univ Porto, Fac Sci, Dept Chem & Biochem, FCUP,LAQV REQUIMTE, P-4169007 Porto, Portugal

[7] UPTEC, Bioprospectum Lda, Sci & Technol Pk Univ Porto, P-4200135 Porto, Portugal

来源：

LWT-FOOD SCIENCE AND TECHNOLOGY | 2021年 / 139卷

关键词：

Antimicrobial activity; Antioxidant activity; Croton betaceus; Croton lundianus; Folk medicine; Hexane fraction; PROFILE; LEAF;

D O I：

10.1016/j.lwt.2020.110521

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The growing microbial resistance to antibiotics and the adverse effects of the frequent use of antimicrobials in oral medicine require products as natural therapeutic alternatives. Croton betaceus and C. lundianus can be viable for in-depth studies in search of new biopmducts. This study evaluated the antioxidant and antimicrobial potential of ethanol extract and leaf fractions of Croton spp. The disk diffusion assay, FRAP and DPPH, were used for antimicrobial and antioxidant analysis, respectively. In addition to phytochemical prospecting and toxicity testing. Secondary metabolites with biological activities were found. Researched extracts and fractions have the potential to inhibit the growth of oral pathogens (Gram-positive, Gram-negative and yeast) in different concentrations. Enterococcus faecalis is the most susceptible to the extract. All fractions showed antioxidant potential. The hexane fraction (BHX and LHX) of both species can inhibit the growth of pathogens in low concentrations, and has a high antioxidant power. The fractions of the extracts of C. betaceus and C. lundianus have important biological activities that can be applied in the development of new antimicrobials for industry and other biotechnological applications.

引用

页数：7

共 45 条

[1] Antimicrobial and Selected In Vitro Enzyme Inhibitory Effects of Leaf Extracts, Flavonols and Indole Alkaloids Isolated from Croton menyharthii [J].

Aderogba, Mutalib A. ;

Ndhlala, Ashwell R. ;

Rengasamy, Kannan R. R. ;

Van Staden, Johannes .

MOLECULES, 2013, 18 (10) :12633-12644

[2] Genotoxic potential of leaf extracts of Jatropha gossypiifolia L. [J].

Almeida, P. M. ;

Araujo, S. S. ;

Santos, I. R. M. R. ;

Marin-Morales, M. A. ;

Benko-Iseppon, A. M. ;

Santos, A. V. ;

Randau, K. P. ;

Brasileiro-Vidal, A. C. .

GENETICS AND MOLECULAR RESEARCH, 2016, 15 (01)

[3] Antiradical Activity, Phenolics Profile, and Hydroxymethylfurfural in Espresso Coffee: Influence of Technological Factors [J].

Alves, Rita C. ;

Costa, Anabela S. G. ;

Jerez, Maria ;

Casal, Susana ;

Sineiro, Jorge ;

Nunez, Maria J. ;

Oliveira, Beatriz .

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2010, 58 (23) :12221-12229

[4]

Aye M. M., 2020, J MYANMAR ACAD ARTS, V18, P171

[5]

BAUER AW, 1966, AM J CLIN PATHOL, V45, P493

[6] The ferric reducing ability of plasma (FRAP) as a measure of ''antioxidant power'': The FRAP assay [J].

Benzie, IFF ;

Strain, JJ .

ANALYTICAL BIOCHEMISTRY, 1996, 239 (01) :70-76

[7]

Bezerra F. W. F., 2020, J SUPERCRITICAL FLUI, V165, P1

[8]

Bhavana R., 2020, Plant Archives, V20, P639

[9]

Calistro L, 2019, PERIODICOS BRASIL ME, V1, P1

[10] Antimicrobial photodynamic therapy reduces adhesion capacity and biofilm formation of Candida albicans from induced oral candidiasis in mice [J].

Carmello, Juliana Cabrini ;

Alves, Fernanda ;

Basso, Fernanda G. ;

de Souza Costa, Carlos Alberto ;

Tedesco, Antonio Claudio ;

Primo, Fernando Lucas ;

de Oliveira Mima, Ewerton Garcia ;

Pavarina, Ana Claudia .

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2019, 27 :402-407

← 1 2 3 4 5 →