Subclinical Hyperthyroidism

被引：93

作者：

Biondi, Bernadette ^{[1
]}

Cooper, David S. ^{[2
]}

机构：

[1] Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy

[2] Johns Hopkins Sch Med, Div Endocrinol Metab & Diabet, 1830 E Monument St,Suite 333, Baltimore, MD 21287 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2018年 / 378卷 / 25期

关键词：

THYROID ASSOCIATION GUIDELINES; PARTICIPANT DATA-ANALYSIS; ALL-CAUSE MORTALITY; QUALITY-OF-LIFE; SERUM THYROTROPIN; CARDIOVASCULAR EVENTS; PROSPECTIVE COHORT; BONE METABOLISM; NATURAL COURSE; DYSFUNCTION;

D O I：

10.1056/NEJMcp1709318

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 65-year-old woman is seen for routine evaluation. She has a history of paroxysmal atrial fibrillation and osteoporosis, which has been treated with a bisphosphonate. She has no history of thyroid disease and reports no symptoms of hyperthyroidism. Her pulse is 80 beats per minute. The left thyroid lobe is enlarged, but the results of physical examination are otherwise normal, as are the results of electrocardiography. The serum thyrotropin level is 0.2 mU per liter (reference range, 0.5 to 4.5) and the free thyroxine (T-4) level 1.2 ng per deciliter (reference range, 0.8 to 1.8). How should this patient be evaluated and treated?

引用

页码：2411 / 2419

页数：9

共 44 条

[1] The association between subclinical thyroid dysfunction and dementia: The Health, Aging and Body Composition (Health ABC) Study [J].

Aubert, Carole E. ;

Bauer, Douglas C. ;

da Costa, Bruno R. ;

Feller, Martin ;

Rieben, Carole ;

Simonsick, Eleanor M. ;

Yaffe, Kristine ;

Rodondi, Nicolas .

CLINICAL ENDOCRINOLOGY, 2017, 87 (05) :617-626

[2] CONTROL OF ADRENERGIC OVERACTIVITY BY BETA-BLOCKADE IMPROVES THE QUALITY-OF-LIFE IN PATIENTS RECEIVING LONG-TERM SUPPRESSIVE THERAPY WITH LEVOTHYROXINE [J].

BIONDI, B ;

FAZIO, S ;

CARELLA, C ;

SABATINI, D ;

AMATO, G ;

CITTADINI, A ;

BELLASTELLA, A ;

LOMBARDI, G ;

SACCA, L .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 78 (05) :1028-1033

[3] Endogenous subclinical hyperthyroidism affects quality of life and cardiac morphology and function in young and middle-aged patients [J].

Biondi, B ;

Palmieri, EA ;

Fazio, S ;

Cosco, C ;

Nocera, M ;

Saccà, L ;

Filetti, S ;

Lombardi, G ;

Perticone, F .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2000, 85 (12) :4701-4705

[4] The clinical significance of subclinical thyroid dysfunction [J].

Biondi, Bernadette ;

Cooper, David S. .

ENDOCRINE REVIEWS, 2008, 29 (01) :76-131

[5] The 2015 European Thyroid Association Guidelines on Diagnosis and Treatment of Endogenous Subclinical Hyperthyroidism [J].

Biondi, Bernadette ;

Bartalena, Luigi ;

Cooper, David S. ;

Hegedus, Laszlo ;

Laurberg, Peter ;

Kahaly, George J. .

EUROPEAN THYROID JOURNAL, 2015, 4 (03) :149-163

[6] Benefits of Thyrotropin Suppression Versus the Risks of Adverse Effects in Differentiated Thyroid Cancer [J].

Biondi, Bernadette ;

Cooper, David S. .

THYROID, 2010, 20 (02) :135-146

[7] Subclinical Thyroid Dysfunction and Fracture Risk A Meta-analysis [J].

Blum, Manuel R. ;

Bauer, Douglas C. ;

Collet, Tinh-Hai ;

Fink, Howard A. ;

Cappola, Anne R. ;

da Costa, Bruno R. ;

Wirth, Christina D. ;

Peeters, Robin P. ;

Asvold, Bjorn O. ;

den Elzen, Wendy P. J. ;

Luben, Robert N. ;

Imaizumi, Misa ;

Bremner, Alexandra P. ;

Gogakos, Apostolos ;

Eastell, Richard ;

Kearney, Patricia M. ;

Strotmeyer, Elsa S. ;

Wallace, Erin R. ;

Hoff, Mari ;

Ceresini, Graziano ;

Rivadeneira, Fernando ;

Uitterlinden, Andre G. ;

Stott, David J. ;

Westendorp, Rudi G. J. ;

Khaw, Kay-Tee ;

Langhammer, Arnuf ;

Ferrucci, Luigi ;

Gussekloo, Jacobijn ;

Williams, Graham R. ;

Walsh, John P. ;

Jueni, Peter ;

Aujesky, Drahomir ;

Rodondi, Nicolas .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2015, 313 (20) :2055-2065

[8] Management of Graves Disease A Review [J].

Burch, Henry B. ;

Cooper, David S. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2015, 314 (23) :2544-2554

[9] Thyroid status, cardiovascular risk, and mortality in older adults [J].

Cappola, AR ;

Fried, LP ;

Arnold, AM ;

Danese, MD ;

Kuller, LH ;

Burke, GL ;

Tracy, RP ;

Ladenson, PW .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 295 (09) :1033-1041

[10] Subclinical thyrotoxicosis: prevalence, causes and choice of therapy [J].

Carle, Allan ;

Andersen, Stine Linding ;

Boelaert, Kristien ;

Laurberg, Peter .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 2017, 176 (06) :R325-R337

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