Anticonvulsant activities of antagonists of NMDA and calcium-permeable AMPA receptors in a model of maximum electroshock in rats

被引：1

作者：

Zaitsev, A. V. ^{[1
]}

Kim, K. Kh ^{[1
]}

Frolova, E. V. ^{[1
]}

Lavrent'eva, V. V. ^{[1
]}

Lukomskaya, N. Ya ^{[1
]}

Magazanik, L. G. ^{[1
,2
]}

机构：

[1] Russian Acad Sci, IM Sechenov Evolut Physiol & Biochem Inst, St Petersburg 196140, Russia

[2] St Petersburg State Univ, Fac Med, St Petersburg 199034, Russia

来源：

NEUROCHEMICAL JOURNAL | 2014年 / 8卷 / 04期

基金：

俄罗斯基础研究基金会;

关键词：

epilepsy; model of maximum electroshock; antagonists of AMPA receptors; glutamate receptors; ANTIEPILEPTIC DRUGS; STATUS EPILEPTICUS; CHANNEL BLOCK; ANIMAL-MODELS; EPILEPSY; TARGET; INTERNEURONS; INHIBITION; SEIZURES; COMPLEX;

D O I：

10.1134/S1819712414040138

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

It is known that activation of ionotropic glutamate receptors plays a leading role in the initiation of seizures and their spreading; however, contribution of one of the subtypes of these receptors, calcium-permeable AMPA receptors (Ca-AMPAR) to seizures is practically unknown. The anticonvulsant action of two Ca-AMPAR blockers, IEM-1754 and IEM-1925, as well as the combination of IEM-1925 with the NMDA channel blocker IEM-1921, was studied in Wistar rats using the maximum electroshock model. It was shown that two Ca-AMPAR blockers are unable to prevent the development of generalized tonic seizures that were induced by electroshock. The combination of IEM-1921 and IEM-1925 did not have a stronger anticonvulsant action than IEM-1921 alone. These results reflect the weak involvement of Ca-AMPAR in the realization of tonic seizures induced by the maximum electroshock.

引用

页码：301 / 305

页数：5

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