Kinetic study of the hydroxide ion attack on and DNA interaction with high spin iron(II) Schiff base amino acid chelates baering ONO donors

被引：12
作者：
Abdel-Rahman, Laila H. [1 ]
El-Khatib, Rafat M. [1 ]
Nassr, Lobna A. E. [1 ]
Abu-Dief, Ahmed M. [1 ]
机构：
[1] Sohag Univ, Dept Chem, Fac Sci, Sohag 82534, Egypt
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2014年 / 84卷 / 09期
关键词：
base catalyzed hydrolysis; reactivity; reaction mechanism; thermodynamic parameters; DNA interaction; COMPLEXES; LIGAND; REACTIVITY; METHANOL; FISSION; CU(II);
D O I：
10.1134/S1070363214090321
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Kinetic study of some novel high spin Fe(II) complexes of Schiff base ligands derived from 5-bromsalicyaldehyde and amino acids with the OH- ion and DNA has been carried out. Based on the kinetic data, the rate law and a plausible mechanism were proposed. Kinetic data of the base catalyzed hydrolysis imply pseudo first-order double stage process due to the presence of mer- and fac-isomers. The observed rate constants k (obs) were correlated with the effect of a substituent R in the structure of ligands. The rate constants and activation parameters are in good agreement with stability constants of the studied complexes. Reactivity of the complexes towards DNA correlated well with the reported binding constants.
引用
收藏
页码：1830 / 1836
页数：7
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