Diterpenoid alkaloids from Aconitum barbatum var. puberulum Ledeb

被引：17

作者：

Ablajan, Nurfida ^{[1
,2
,4
]}

Zhao, Bo ^{[1
,2
]}

Zhao, Jiang-Yu ^{[1
,2
]}

Wang, Bian-Lin ^{[1
,2
]}

Sagdullaev, Sh Sh ^{[3
]}

Aisa, H. A. ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, State Key Lab Basis Xinjiang Indigenous Med Plant, Beijing South Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China

[2] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plants Resources & Chem Arid Zone, Beijing South Rd 40-1, Urumqi 830011, Xinjiang, Peoples R China

[3] Acad Sci Uzbek, SYu Yunusov Inst Chem Plant Subst, Tashkent, Uzbekistan

[4] Univ Chinese Acad Sci, Beijing 100039, Peoples R China

来源：

PHYTOCHEMISTRY | 2021年 / 181卷

基金：

对外科技合作项目（国际科技项目）;

关键词：

Aconitum barbatum var. puberulum Ledeb; Ranunculaceae; Diterpenoid alkaloids; Barpuberudine; Barpubesines; Barpubenines; Biological activities;

D O I：

10.1016/j.phytochem.2020.112567

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven previously undescribed diterpenoid alkaloids, including five C-20-diterpenoid alkaloids, barpuberudine, barpubesines A-D, and two C-18-diterpenoid alkaloids, barpubenines A-B, along with 11 known diterpenoid alkaloids were isolated from the whole plant of Aconitum barbatum var. puberulum Ledeb. (Ranunculaceae). Barpuberudine is an unprecedented carbon skeleton of C-20-diterpenoid alkaloid, while barpubenines A-B are the first example of rearranged types in C-18-diterpenoid alkaloids. Their structures were elucidated based on a comprehensive spectroscopic data analysis. The probable pathway of biogenesis of barpuberudine and barpubenines A-B were discussed. Additionally, the antiarrhythmic, cytotoxic and antimicrobial activities of isolates were also evaluated.

引用

页数：9