Synthesis, Structure, and Biological Activity of 2,6-Disubstituted 2,3a,4a,6,7a,8a-Hexaazaperhydrocyclopenta[def]fluorene-4-thioxo-8-ones

被引：12

作者：

Barsegyan, Yana A. ^{[1
,2
]}

Baranov, Vladimir V. ^{[1
]}

Kravchenko, Angelina N. ^{[1
]}

Strelenko, Yuri A. ^{[1
]}

Anikina, Lada V. ^{[3
]}

Karnoukhova, Valentina A. ^{[4
]}

Kolotyrkina, Natalya G. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia

[2] D Mendeleev Univ Chem Technol Russia, Miusskaya Sq 9, Moscow 125047, Russia

[3] Russian Acad Sci, Inst Physiol Act Subst, Chernogolovka, Moscow Oblast, Russia

[4] Russian Acad Sci, AN Nesmeyanov Inst Organoelement Cpds, Moscow 119991, Russia

来源：

SYNTHESIS-STUTTGART | 2018年 / 50卷 / 10期

基金：

俄罗斯科学基金会;

关键词：

multicomponent reaction; one-pot condensation; thioglycolurils; polyheterocyclic compounds; antifungal activity; BAMBUSURIL MACROCYCLE; GLYCOLURIL; THIOGLYCOLURILS; ANIONS; ACIDS;

D O I：

10.1055/s-0036-1591952

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A two-step one-pot condensation for the synthesis of previously inaccessible 2,6-disubstituted 2,3a,4a,6,7a,8a-hexaazaperhydrocyclopenta[def ]fluorene-4-thioxo-8-ones from simple reagents [5-thioxohexahydroimidazo[4,5- d]imidazol-2(1H )-one, paraformaldehyde and amines] was developed. The structure, antimicrobial, and anticancer activity of a number of synthesized compounds were studied.

引用

页码：2099 / 2105

页数：7

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