Effect of Cyclopentyladenosine on Lipid Peroxidation during Focal Cerebral Ischemia

被引：7
|
作者：
Sufianova, G. Z. [1 ]
Sufianov, A. A. [2 ]
Shapkin, A. G. [2 ]
机构：
[1] Russian Minist Hlth, Tyumen State Med Acad, Dept Pharmacol, Tyumen, Russia
[2] Minist Hlth Russian Federat, Fed Ctr Neurosurg, Tyumen, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2014年 / 157卷 / 02期
关键词：
cyclopentyladenosine; adenosine A1 receptor agonist; cerebral ischemia; lipid peroxidation; antioxidant defense; ADENOSINE; RECEPTORS; DISEASE;
D O I：
10.1007/s10517-014-2531-z
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The antioxidant effect of an adenosine A(1) receptor agonist cyclopentyladenosine was studied on the model of focal cerebral ischemia. Ischemic injury of the brain was accompanied by changes in LPO processes (in the blood and brain tissue) and failure of some factors for antioxidant protection (peroxidase and catalase) that inactivate reactive metabolites. Changes in the ratio between LPO and antioxidant protection were less pronounced after treatment with cyclopentyladenosine.
引用
收藏
页码：228 / 230
页数：3
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