Targeting RNA-binding proteins in acute and chronic leukemia

被引：17

作者：

Elcheva, Irina A. ^{[1
]}

Spiegelman, Vladimir S. ^{[1
]}

机构：

[1] Penn State Univ, Coll Med, Dept Pediat, Div Pediat Hematol & Oncol, Hershey, PA 17033 USA

来源：

LEUKEMIA | 2021年 / 35卷 / 02期

关键词：

STEM-CELL MAINTENANCE; MYELOID-LEUKEMIA; SELF-RENEWAL; ADAR1; DIFFERENTIATION; HEMATOPOIESIS; MUTATIONS; CONTRIBUTES; DEMETHYLASE; INHIBITOR;

D O I：

10.1038/s41375-020-01066-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

RNA-binding proteins (RBPs) play a crucial role in cellular physiology by regulating RNA processing, translation, and turnover. In neoplasms, RBP support of cancer-relevant expression of alternatively spliced, modified, and stabilized mRNA transcripts is essential to self-renewal, proliferation, and adaptation to stress. In this review, we assess the impact of key families of RBPs in leukemogenesis, review progress in targeting those proteins with small molecules, and discuss how multilevel composition of posttranscriptional regulation of gene expression could be used for potential therapies in acute and chronic leukemia.

引用

页码：360 / 376

页数：17

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