Two new sesquiterpene coumarins from the seeds of Ferula sinkiangensis

被引：21
|
作者：
Li, Guangzhi [1 ]
Wang, Junchi [1 ]
Li, Xiaojin [2 ]
Cao, Li [1 ]
Lv, Na [1 ]
Chen, Gang [2 ]
Zhu, Jun [2 ]
Si, Jianyong [1 ]
机构：
[1] Chinese Acad Med Sci, Peking Union Med Coll, Inst Med Plant Dev, Beijing 100193, Peoples R China
[2] Xinjiang Inst Chinese Mat Med & Eth Mat Med, Urumqi 830002, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2015年 / 13卷
基金：
中国国家自然科学基金;
关键词：
Ferula sinkiangensis; Sesquiterpene coumarin; Cytotoxic activities;
D O I：
10.1016/j.phytol.2015.06.002
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new sesquiterpene coumarins, namely, sinkiangenorin F (1) and 8-O-acetyl sinkiangenorin F (2) were isolated from the seeds of Ferula sinkiangensis. The structures of the new compounds, including the relative stereochemistry and the absolute configuration were elucidated through extensive spectroscopic methods. The two compounds were tested against the K562, HeLa, and AGS human cancer cell lines and showed cytotoxic activities with 50% inhibitory concentration values between 27.1 and 62.7 mu M. (C) 2015 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：123 / 126
页数：4
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