Di-tert-butyl Peroxide (DTBP)-Mediated Oxysilylation of Unsaturated Carboxylic Acids for the Synthesis of Silyl Lactones

被引：28

作者：

Nozawa-Kumada, Kanako ^{[1
]}

Ojima, Takuto ^{[1
]}

Inagi, Moeto ^{[1
]}

Shigeno, Masanori ^{[1
]}

Kondo, Yoshinori ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 24期

基金：

日本学术振兴会;

关键词：

INTRAMOLECULAR BIS-SILYLATION; C-H SILYLATION; STEREOSELECTIVE-SYNTHESIS; COOPERATIVE PHOTOREDOX; ALKENES; HYDROSILYLATION; ACCESS; LACTONIZATION; ACTIVATION; ELECTRON;

D O I：

10.1021/acs.orglett.0c03640

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein, we describe the first oxysilylation of unsaturated carboxylic acids mediated by di-tert-butyl peroxide (DTBP), which enables the rapid and efficient preparation of silyl lactone compounds. This process tolerates functional groups, such as methyl, methoxy, halogen (fluoride and chloride), and cyano moieties. Furthermore, the strategy allows the application of a wide range of primary, secondary, and tertiary hydrosilanes for functionalization.

引用

收藏

页码：9591 / 9596

页数：6

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