A novel approach for the adsorption of iodine-125 on silver wire as matrix for brachytherapy source for the treatment of eye and prostate cancer

被引：40

作者：

Mathew, C ^{[1
]}

Majali, MA ^{[1
]}

Balakrishnan, SA ^{[1
]}

机构：

[1] Bhabha Atom Res Ctr, Radiopharmaceut Div, Bombay 400085, Maharashtra, India

来源：

APPLIED RADIATION AND ISOTOPES | 2002年 / 57卷 / 03期

关键词：

iodine-125; brachytherapy; implant; interstitial source; eye cancer;

D O I：

10.1016/S0969-8043(02)00099-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The adsorption of iodine-125 on silver wire bits coated with palladium to be sealed in titanium capsules as brachytherapy sources was studied. A method was optimized to obtain quantitative adsorption of I-125 on the palladium treated silver wires. A comparative evaluation of palladium coated and uncoated (bare) silver wires on the adsorption of I-125 was made. While, the adsorption of bare silver wires showed low, inconsistent uptake (similar to60%) of I-125 with high leachability (similar to4%), the Pd coated silver wires showed quantitative and consistent uptake of I-125 (similar to90%) and exhibited low leachability (0.01%). I-125 adsorbed on Pd coated silver wires could be used as a matrix for the preparation of interstitial sources in eye and prostate cancer therapy. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：359 / 367

页数：9

共 9 条

[1] IMPLEMENTATION OF THE COINCIDENCE METHOD FOR DETERMINING I-125 ACTIVITY WITH AN ESTIMATE OF ERROR [J].

EDISS, C ;

ABRAMS, DN .

JOURNAL OF RADIOANALYTICAL CHEMISTRY, 1981, 65 (1-2) :341-347

[2] Monte Carlo-aided dosimetry of the symmetra model I25,S06 125I, interstitial brachytherapy seed [J].

Hedtjärn, H ;

Carlsson, GA ;

Williamson, JF .

MEDICAL PHYSICS, 2000, 27 (05) :1076-1085

[3] EXPOSURE CONTRIBUTION FROM TI K X-RAYS PRODUCED IN THE TITANIUM CAPSULE OF THE CLINICAL I125 SEED [J].

KUBO, H .

MEDICAL PHYSICS, 1985, 12 (02) :215-220

[4]

Linke W.F., 1965, J AM CHEM SOC, P662

[5]

LINKE WF, 1958, INORGANIC METAL ORGA, V1

[6] Experimental determination of dosimetric characteristics of Best® 125I brachytherapy source [J].

Meigooni, AS ;

Gearheart, DM ;

Sowards, K .

MEDICAL PHYSICS, 2000, 27 (09) :2168-2173

[7] Dose distribution along the transverse axis of a new 125I source for interstitial brachytherapy [J].

Nath, R ;

Yue, N .

MEDICAL PHYSICS, 2000, 27 (11) :2536-2540

[8] Dosimetric characteristics of the Pharma Seed™ model BT-125-I source [J].

Popescu, CC ;

Wise, J ;

Sowards, K ;

Meigooni, AS ;

Ibbott, GS .

MEDICAL PHYSICS, 2000, 27 (09) :2174-2181

[9] THE DOSIMETRY OF I-125 SEED EYE PLAQUES [J].

WEAVER, KA .

MEDICAL PHYSICS, 1986, 13 (01) :78-83

← 1 →