Long chain phenols. Part 41A. The synthesis of 2-hydroxymethyl derivatives of phenols

被引：0
|
作者：
Payne, Peter
Tyman, John H. P. [1 ]
Mehet, Satinder K.
Ninagawa, Akira
机构：
[1] Brunel Univ, Dept Chem, Uxbridge UB8 2PH, Middx, England
[2] Osaka Univ, Dept Appl Chem, Osaka 565, Japan
来源：
JOURNAL OF CHEMICAL RESEARCH-S | 2006年 / 06期
关键词：
alkylphenols; 2-hydroxymethylphenols; bishydroxymethylphenols; 2-hydroxylbenzaldehydes; sodium borohydride reduction; cardanol; t-nonylphenol [4-(3,5,5-trimethylhexyl)phenol; formaldehyde;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
2-Hydroxymethylphenols have been prepared in good yield by reduction with sodium borohydride of the precursor aldehydes, obtained regiospecifically from reaction of phenols with paraformaldehyde in toluene containing stannic chloride and tri-n-butylamine. By contrast, reaction of phenols with either paraformaldehyde under anhydrous conditions or with aqueous formaldehyde results in formation of both the hydroxymethyl and the bishydroxymethyl derivatives. Cyclic acetals of the precursor aldehydes are readily accessible.
引用
收藏
页码：402 / 405
页数：4
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