Social Defeat as an Animal Model for Depression

被引：173
作者：
Hollis, Fiona [1 ]
Kabbaj, Mohamed [2 ]
机构：
[1] Ecole Polytech Fed Lausanne, Brain Mind Inst, Lausanne, Switzerland
[2] Florida State Univ, Coll Med, Dept Biomed Sci, Tallahassee, FL 32306 USA
来源：
ILAR JOURNAL | 2014年 / 55卷 / 02期
关键词：
animal models; depression; social defeat; stress; RECURRENT MAJOR DEPRESSION; NOVELTY-SEEKING BEHAVIOR; GENOME-WIDE ASSOCIATION; PITUITARY-ADRENAL AXIS; STRESSFUL LIFE EVENTS; INDIVIDUAL-DIFFERENCES; NUCLEUS-ACCUMBENS; HIPPOCAMPAL NEUROGENESIS; NEUROTROPHIC FACTOR; ANTIDEPRESSANT TREATMENT;
D O I：
10.1093/ilar/ilu002
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
Depression is one of the most disabling medical conditions in the world today, yet its etiologies remain unclear and current treatments are not wholly effective. Animal models are a powerful tool to investigate possible causes and treatments for human diseases. We describe an animal model of social defeat as a possible model for human depression. We discuss the paradigm, behavioral correlates to depression, and potential underlying neurobiological mechanisms with an eye toward possible future therapies.
引用
收藏
页码：221 / 232
页数：12
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