Combination therapy of disseminated Fusarium oxysporum infection with terbinafine and amphotericin B

被引：41

作者：

Rothe, A

Seibold, M

Hoppe, T

Seifert, H

Engert, A

Caspar, C

Karthaus, M

Fätkenheuer, G

Bethe, U

Tintelnot, K

Cornely, OA

机构：

[1] Univ Cologne, Innere Med Klin 1, D-50931 Cologne, Germany

[2] Robert Koch Inst, D-13353 Berlin, Germany

[3] Univ Cologne, Inst Med Mikrobiol Immunol & Hyg, D-50935 Cologne, Germany

[4] Univ Cologne, Klin & Poliklin Dermatol & Venerol, D-50935 Cologne, Germany

[5] Ev Johannes Krankenhaus, Med Klin 2, D-33611 Bielefeld, Germany

来源：

ANNALS OF HEMATOLOGY | 2004年 / 83卷 / 06期

关键词：

disseminated fusariosis; Fusarium oxysporum; febrile neutropenia; fungemia; skin lesions; combination therapy;

D O I：

10.1007/s00277-003-0795-x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A case of disseminated infection with Fusarium oxysporum following chemotherapy of acute myelogenous leukemia is reported. Antifungal treatment was successful with a 13-day course of oral terbinafine 250 mg t.i.d. in combination with amphotericin B deoxycholate 1.0-1.5 mg/kg qd and subsequently intravenous liposomal amphotericin B 5 mg/kg qd. Preceding monotherapy with amphotericin B deoxycholate 1.0-1.5 mg/kg qd had not stopped the progression of infection. The combination therapy described here represents a novel approach to the treatment of Fusarium spp. in the immunocompromised host in whom Fusarium spp. are known to cause disseminated infection with high mortality.

引用

页码：394 / 397

页数：4

共 17 条

[1] Fusariosis associated with pathogenic Fusarium species colonization of a hospital water system:: A new paradigm for the epidemiology of opportunistic mold infections [J].