Mesenchymal Stem Cell Secretome as an Emerging Cell-Free Alternative for Improving Wound Repair

被引：128

作者：

Ahangar, Parinaz ^{[1
,2
]}

Mills, Stuart J. ^{[1
]}

Cowin, Allison J. ^{[1
]}

机构：

[1] Univ South Australia, Future Ind Inst, Adelaide, SA 5000, Australia

[2] Univ South Australia, Clin & Hlth Sci, Adelaide, SA 5000, Australia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 19期

基金：

英国医学研究理事会;

关键词：

mesenchymal stem cells; secretome; wound healing; STROMAL CELLS; GROWTH-FACTOR; SKIN; DIFFERENTIATION; PROLIFERATION; FIBROBLAST; INCREASE; SURVIVAL; CULTURE; MUSCLE;

D O I：

10.3390/ijms21197038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The use of mesenchymal stem cells (MSC) for the treatment of cutaneous wounds is currently of enormous interest. However, the broad translation of cell therapies into clinical use is hampered by their efficacy, safety, manufacturing and cost. MSCs release a broad repertoire of trophic factors and immunomodulatory cytokines, referred to as the MSC secretome, that has considerable potential for the treatment of cutaneous wounds as a cell-free therapy. In this review, we outline the current status of MSCs as a treatment for cutaneous wounds and introduce the potential of the MSC secretome as a cell-free alternative for wound repair. We discuss the challenges and provide insights and perspectives for the future development of the MSC secretome as well as identify its potential clinical translation into a therapeutic treatment.

引用

页码：1 / 15

页数：15

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