Non-tuberculous mycobacteria in the sputum of HIV-infected patients: infection or colonization?

被引：9

作者：

Alvarez-Uria, G. ^{[1
,3
]}

Falco, V. ^{[1
,3
]}

Martin-Casabona, N. ^{[2
,3
]}

Crespo, M. ^{[1
]}

del Saz, S. Villar ^{[1
]}

Curran, A. ^{[1
]}

Ocana, I. ^{[1
,3
]}

Ribera, E. ^{[1
]}

Pahissa, A. ^{[1
,3
]}

机构：

[1] Vall Hebron Univ Hosp, Dept Infect Dis, Barcelona, Spain

[2] Vall Hebron Univ Hosp, Dept Microbiol, Barcelona, Spain

[3] Univ Autonoma Barcelona, Dept Med, E-08193 Barcelona, Spain

来源：

INTERNATIONAL JOURNAL OF STD & AIDS | 2009年 / 20卷 / 03期

关键词：

Mycobacterium avium complex; Mycobacterium kansasii; Mycobacterium xenopi; haemoglobin; CD4 lymphocyte count; HUMAN-IMMUNODEFICIENCY-VIRUS; AVIUM COMPLEX DISEASE; UNITED-STATES; MANIFESTATIONS; EPIDEMIOLOGY; KANSASII; XENOPI;

D O I：

10.1258/ijsa.2008.008300

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

It can be difficult to establish the clinical significance of the isolation of non-tuberculous mycobacteria (NTM) from the sputum of HIV-infected patients. In this observational study, we have investigated factors associated with having NTM infection. During the period of the study, 10 patients had NTM infection and 14 had NTM colonization. Factors associated with having NTM infections were: CD4 lymphocyte count <50 cells/mL (odds ratio [OR] 10; 95% confidence interval [CI] 1.4-69.3), haemoglobin <11 g/dL (OR 7.2; 95% CI 1.08-47.9), weight loss (OR 9; 95% CI 1.3-63.9), duration of symptoms for more than a month (OR 54; 95% CI 4.2-692.5), the presence of acid fast bacilli (AFB) in sputum (OR 30.3; 95% Cl 2.6-348.9) and repeated positive NTM cultures in other sputum samples (OR 4.3; 95% CI 1.6-11.7). In conclusion, we must suspect NTM infection in patients with long-standing symptoms, anaemia, low CD4 lymphocyte count, several positive sputum cultures and when AFB are seen.

引用

页码：193 / 195

页数：3

共 14 条

[1] Nontuberculous mycobacteria in the environment [J].