Zinc-Catalyzed Dehydrogenative Cross-Coupling of Terminal Alkynes with Aldehydes: Access to Ynones

被引：45

作者：

Tang, Shan ^{[1
]}

Zeng, Li ^{[1
]}

Liu, Yichang ^{[1
]}

Lei, Aiwen ^{[1
,2
]}

机构：

[1] Wuhan Univ, Inst Adv Studies, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China

[2] Jiangxi Normal Univ, Natl Res Ctr Carbohydrate Synth, Nanchang 330022, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 52期

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

C-H activation; cross-coupling; dehydrogenation; homogeneous catalysis; zinc; ALPHA-KETO ACIDS; DECARBOXYLATIVE ALKYNYLATION; PROPARGYLIC ALCOHOLS; SONOGASHIRA REACTION; DIRECT ADDITION; ACTIVATION; CONVENIENT; GENERATION; DISCOVERY; REAGENTS;

D O I：

10.1002/anie.201509042

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Because of the lack of redox ability, zinc has seldom been used as a catalyst in dehydrogenative cross-coupling reactions. Herein, a novel zinc-catalyzed dehydrogenative C(sp(2))-H/C(sp)-H cross-coupling of terminal alkynes with aldehydes was developed, and provides a simple way to access ynones from readily available materials under mild reaction conditions. Good reaction selectivity can be achieved with a 1: 1 ratio of terminal alkyne and aldehyde. Various terminal alkynes and aldehydes are suitable in this transformation.

引用

页码：15850 / 15853

页数：4

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