The Role of Histone Variants in the Epithelial-To-Mesenchymal Transition

被引：2
作者：
Lone, Imtiaz Nisar [1 ]
Sengez, Burcu [1 ,2 ]
Hamiche, Ali [3 ]
Dimitrov, Stefan [1 ,4 ]
Alotaibi, Hani [1 ,2 ]
机构：
[1] Izmir Biomed & Genome Ctr, TR-35340 Izmir, Turkey
[2] Dokuz Eylul Univ, Izmir Int Biomed & Genome Inst, TR-35340 Izmir, Turkey
[3] Inst Genet & Mol & Cellular Biol IGBMC, 1 Rue Laurent Fries, F-67400 Illkirch Graffenstaden, France
[4] Univ Grenoble Alpes, Inst Adv Biosci IAB, INSERM U1209, CNRS UMR 5309, Site Sante Allee Alpes, F-38700 La Tronche, France
来源：
CELLS | 2020年 / 9卷 / 11期
关键词：
epithelial-to-mesenchymal transition; epigenetics; chromatin; nucleosomes; histone variants; NUCLEOSOME CORE PARTICLE; FUNCTIONAL-PROPERTIES; CELL-CYCLE; H2A.Z; TRANSCRIPTION; MACROH2A; CHROMATIN; PHOSPHORYLATION; INTERFERES; CHAPERONE;
D O I：
10.3390/cells9112499
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The epithelial-to-mesenchymal transition (EMT) is a physiological process activated during early embryogenesis, which continues to shape tissues and organs later on. It is also hijacked by tumor cells during metastasis. The regulation of EMT has been the focus of many research groups culminating in the last few years and resulting in an elaborate transcriptional network buildup. However, the implication of epigenetic factors in the control of EMT is still in its infancy. Recent discoveries pointed out that histone variants, which are key epigenetic players, appear to be involved in EMT control. This review summarizes the available data on histone variants' function in EMT that would contribute to a better understanding of EMT itself and EMT-related diseases.
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页码：1 / 11
页数：11
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