TARGETING WILDTYPE IL-2 TO CD8 T CELLS INDUCES POTENT ANTI-TUMOR IMMUNE RESPONSES AND DECREASES IL-2 MEDIATED TOXICITY

被引:0
|
作者
Ramasamy, Selvi [1 ]
Nardozzi, Joanathan [1 ]
Boi, Shannon [1 ]
Swain, Joanna [1 ]
Coyle, Anthony [1 ]
Gulla, Stefano [1 ]
机构
[1] Repertoire Immune Med, Cambridge, MA USA
关键词
D O I
10.1136/jitc-2022-SITC2022.1098
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
1098
引用
收藏
页码:A1141 / A1141
页数:1
相关论文
共 50 条
  • [21] Regulatory T cells suppress the formation of potent KLRK1 and IL-7R expressing effector CD8 T cells by limiting IL-2
    Tsyklauri, Oksana
    Chadimova, Tereza
    Niederlova, Veronika
    Kovarova, Jirina
    Michalik, Juraj
    Malatova, Iva
    Janusova, Sarka
    Ivashchenko, Olha
    Rossez, Helene
    Drobek, Ales
    Vecerova, Hana
    Galati, Virginie
    Kovar, Marek
    Stepanek, Ondrej
    ELIFE, 2023, 12
  • [22] Subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production
    Kronin, V
    Winkel, K
    Suss, G
    Kelso, A
    Heath, W
    Kirberg, J
    vonBoehmer, H
    Shortman, K
    JOURNAL OF IMMUNOLOGY, 1996, 157 (09): : 3819 - 3827
  • [23] IL-2 and IL-15 on CD8 T cells during chronic viral infection: The exhaustion program awakens
    Beltra, Jean-Christophe
    Bourbonnais, Sara
    Bedard, Nathalie
    Charpentier, Tania
    Boulange, Moana
    Michaud, Eva
    Boufaied, Ines
    Bruneau, Julie
    Shoukry, Naglaa H.
    Lamarre, Alain
    Decaluwe, Helene
    JOURNAL OF IMMUNOLOGY, 2016, 196
  • [24] IL-2 immunotherapy for targeting regulatory T cells in autoimmunity
    Lykhopiy, Valentina
    Malviya, Vanshika
    Humblet-Baron, Stephanie
    Schlenner, Susan M.
    GENES AND IMMUNITY, 2023, 24 (05) : 248 - 262
  • [25] INTRATUMORAL ADMINISTRATION AND LOCAL RETENTION OF IL-2/IL-12 FUSION PROTEINS DRIVE A POTENT SYSTEMIC ANTI-TUMOR IMMUNE RESPONSE
    Naveen, Mehta
    Li, Bochong
    Wittrup, Dane
    Baeuerle, Patrick
    Michaelson, Jennifer
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A918 - A918
  • [26] IL-2 production by virus- and tumor-specific human CD8 T cells is determined by their fine specificity
    Mallard, E
    Vernel-Pauillac, F
    Velu, T
    Lehmann, F
    Abastado, JP
    Salcedo, M
    Bercovici, N
    JOURNAL OF IMMUNOLOGY, 2004, 172 (06): : 3963 - 3970
  • [27] IL-2 immunotherapy for targeting regulatory T cells in autoimmunity
    Valentina Lykhopiy
    Vanshika Malviya
    Stephanie Humblet-Baron
    Susan M. Schlenner
    Genes & Immunity, 2023, 24 (5): : 248 - 262
  • [28] Opposing effects of IL-2 in tumor immunotherapy: Promoting CD8 T cell growth and inducing apoptosis
    Shrikant, P
    Mescher, MF
    JOURNAL OF IMMUNOLOGY, 2002, 169 (04): : 1753 - 1759
  • [29] Generation of Potent Tumor-Specific CTLs from High-Dose IL-2 Activated naive CD8 T Cells with Overcoming the Tumor-Derived Immune Suppression
    Nguyen, Hong-Hanh
    Kim, Dong-hwan
    Lee, Hyun-Ju
    Jung, Sung-Hoon
    Kim, Hyeoung-Joon
    Lee, Je-Jung
    Yang, Deok-Hwan
    BLOOD, 2014, 124 (21)
  • [30] IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis
    Humblet-Baron, Stephanie
    Franckaert, Dean
    Dooley, James
    Bornschein, Simon
    Cauwe, Benedicte
    Schonefeldt, Susann
    Bossuyt, Xavier
    Matthys, Patrick
    Baron, Frederic
    Wouters, Carine
    Liston, Adrian
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2016, 138 (01) : 200 - +