Synthesis of new 2-[1(2H)-phthalazinon-2-yl]-acetamide and 3-[1(2H)-phthalazinon-2-yl]-propanamide derivatives as antinociceptive and anti-inflammatory agents

被引：56

作者：

Dogruer, DS

Kupeli, E

Yesilada, E

Sahin, MF ^{[1
]}

机构：

[1] Gazi Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06330 Ankara, Turkey

[2] Gazi Univ, Fac Pharm, Dept Pharmacognosy, TR-06330 Ankara, Turkey

来源：

ARCHIV DER PHARMAZIE | 2004年 / 337卷 / 06期

关键词：

1(2H); phthalazinone; antinociceptive; anti-inflammatory;

D O I：

10.1002/ardp.200200719

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

As a consequence of our ongoing studies on heterocyclic compounds for new antinociceptive and anti-inflammatory agents bearing lactam functional group, new 2-[1(2H)-phthalazinon-2-yl]acetamide and 3-[1(2H)-phthalazinon-2-yl]propanamide derivatives have been synthesized. Among the compounds synthesized, compound 4e was found the most active derivative in terms of antinociceptive and anti-inflammatory activities, without gastric lesions and bleeding at the given dose.

引用

页码：303 / 310

页数：8

共 18 条

[1]

Dogruer DS, 1997, FARMACO, V52, P745

[2]

Dogruer DS, 2000, ARCH PHARM, V333, P79, DOI 10.1002/(SICI)1521-4184(20004)333:4<79::AID-ARDP79>3.0.CO

[3]

2-S

[4] Anti-nociceptive and anti-inflammatory activity of some (2-benzoxazolone-3-yl and 2-benzothiazolone-3-yl)acetic acid derivatives [J].