G-Protein Coupled Receptor 124 (GPR124) in Endothelial Cells Regulates Vascular Endothelial Growth Factor (VEGF)-Induced Tumor Angiogenesis

被引：31
|
作者：
Wang, Y. [1 ,2 ]
Cho, S. -G. [2 ,3 ]
Wu, X. [1 ]
Siwko, S. [2 ]
Liu, M. [2 ,4 ,5 ]
机构：
[1] Hunan Normal Univ, Coll Life Sci, Ctr Heart Dev, Key Lab MOE Dev Biol & Prot Chem, Changsha 410081, Hunan, Peoples R China
[2] Texas A&M Univ, Hlth Sci Ctr, Inst Biosci & Technol, Ctr Canc & Stem Cell Biol, Houston, TX 77030 USA
[3] Kyung Hee Univ, Coll Korean Med, Dept Prevent Med, Seoul, South Korea
[4] E China Normal Univ, Inst Biomed Sci, Shanghai Key Lab Regulatory Biol, Shanghai 200062, Peoples R China
[5] E China Normal Univ, Sch Life Sci, Shanghai 200062, Peoples R China
来源：
CURRENT MOLECULAR MEDICINE | 2014年 / 14卷 / 04期
基金：
中国国家自然科学基金;
关键词：
Angiogenesis; cancer; G protein coupled receptors (GPCR); tumor; vascular biology; vascular endothelial growth factor (VEGF); FOCAL ADHESION KINASE; BREAST-CANCER; VEGF EXPRESSION; ACTIVATION; PHOSPHORYLATION; MARKER; MECHANISM; THERAPY; TARGET; PROLIFERATION;
D O I：
10.2174/1566524014666140414205943
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
G protein-coupled receptor 124 (GPR124; also called tumor endothelial marker 5, TEM5) is highly expressed in tumor vasculature. While recent studies have revealed a role in vasculogenesis, evidence for GPR124 function in tumor angiogenesis is lacking. Here, we demonstrate that GPR124 is required for VEGF-induced tumor angiogenesis. GPR124 silencing in human endothelial cells inhibited mouse xenograft tumor angiogenic vessel formation and tumor growth. GPR124 regulated VEGF-induced tumor angiogenic processes in vitro including cell-cell interaction, permeability, migration, invasion, and tube formation. Therefore, GPR124 plays a key role in VEGF-induced tumor angiogenesis.
引用
收藏
页码：543 / 554
页数：12
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