Gleaning evolutionary insights from the genome sequence of a probiotic yeast Saccharomyces boulardii

被引：19

作者：

Khatri, Indu ^{[1
]}

Akhtar, Akil ^{[1
]}

Kaur, Kamaldeep ^{[1
]}

Tomar, Rajul ^{[1
]}

Prasad, Gandham Satyanarayana ^{[1
]}

Ramya, Thirumalai Nallan Chakravarthy ^{[1
]}

Subramanian, Srikrishna ^{[1
]}

机构：

[1] CSIR Inst Microbial Technol, Chandigarh, India

来源：

GUT PATHOGENS | 2013年 / 5卷

关键词：

Diarrhea; Human gut; Clostridium difficile; Enterohemorrhagic Escherichia coli; CLOSTRIDIUM-DIFFICILE; CEREVISIAE; DATABASE; INHIBITION; ADHERENCE; STRAINS; SAFETY; GENES;

D O I：

10.1186/1757-4749-5-30

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: The yeast Saccharomyces boulardii is used worldwide as a probiotic to alleviate the effects of several gastrointestinal diseases and control antibiotics-associated diarrhea. While many studies report the probiotic effects of S. boulardii, no genome information for this yeast is currently available in the public domain. Results: We report the 11.4 Mbp draft genome of this probiotic yeast. The draft genome was obtained by assembling Roche 454 FLX + shotgun data into 194 contigs with an N50 of 251 Kbp. We compare our draft genome with all other Saccharomyces cerevisiae genomes. Conclusions: Our analysis confirms the close similarity of S. boulardii to S. cerevisiae strains and provides a framework to understand the probiotic effects of this yeast, which exhibits unique physiological and metabolic properties.

引用

页数：8

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