Double Hydrophilic Block Copolymers for Doxorubicin Delivery

被引：2

作者：

Kunitskaya, Larisa ^{[1
]}

Zheltonozhskaya, Tatyana ^{[1
]}

Permyakova, Natalia ^{[1
]}

Kobylinska, Natalia ^{[2
]}

机构：

[1] Taras Shevchenko Natl Univ Kiev, Macromol Chem Dept, Fac Chem, UA-01033 Kiev, Ukraine

[2] Taras Shevchenko Natl Univ Kiev, Dept Analyt Chem, Fac Chem, UA-01033 Kiev, Ukraine

来源：

MOLECULAR CRYSTALS AND LIQUID CRYSTALS | 2014年 / 590卷 / 01期

关键词：

Amphiphilic block copolymers; doxorubicin; micellization; poly (ethylene oxide); polyacrylamide; MICELLES; POLYMER; ACID;

D O I：

10.1080/15421406.2013.874179

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The anionic derivative of asymmetric triblock copolymer containing biocompatible chemically complementary polyacrylamide and poly(ethylene oxide) (PAAm-b-PEO-b-PAAm) was obtained. The micellization of the initial (TBC) and modified (TBC-COOH) copolymer samples in aqueous solution were investigated. The similar values of the critical micellization concentration and the Gibbs free micellization energy for initial and modified TBCs were found. The anticancer effects of the doxorubicin (DOX)-loaded micelles of the initial and modified triblock copolymers were studied. The fact of higher efficacy of DOX/TBC and DOX/TBC-COOH compositions in compare with pure DOX was determined and discussed.

引用

页码：164 / 171

页数：8

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