Extracellular Matrix, a Hard Player in Angiogenesis

被引:158
作者
Mongiat, Maurizio [1 ]
Andreuzzi, Eva [1 ]
Tarticchio, Giulia [1 ]
Paulitti, Alice [1 ]
机构
[1] CRO IRCCS, Dept Translat Res, Expt Oncol Div 2, I-33081 Aviano, Italy
关键词
extracellular matrix; angiogenesis; tumor microenvironment; FIBROBLAST-GROWTH-FACTOR; HEPARAN-SULFATE PROTEOGLYCANS; RECOMBINANT HUMAN ENDOSTATIN; PERLECAN PROTEIN CORE; FACTOR RECEPTOR 2; ENDOTHELIAL-CELL PROLIFERATION; MOLECULAR-WEIGHT HYALURONAN; COLLAGEN TYPE-IV; TUMOR-GROWTH; IN-VITRO;
D O I
10.3390/ijms17111822
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The extracellular matrix (ECM) is a complex network of proteins, glycoproteins, proteoglycans, and polysaccharides. Through multiple interactions with each other and the cell surface receptors, not only the ECM determines the physical and mechanical properties of the tissues, but also profoundly influences cell behavior and many physiological and pathological processes. One of the functions that have been extensively explored is its impingement on angiogenesis. The strong impact of the ECM in this context is both direct and indirect by virtue of its ability to interact and/ or store several growth factors and cytokines. The aim of this review is to provide some examples of the complex molecular mechanisms that are elicited by these molecules in promoting or weakening the angiogenic processes. The scenario is intricate, since matrix remodeling often generates fragments displaying opposite effects compared to those exerted by the whole molecules. Thus, the balance will tilt towards angiogenesis or angiostasis depending on the relative expression of pro-or anti-angiogenetic molecules/ fragments composing the matrix of a given tissue. One of the vital aspects of this field of research is that, for its endogenous nature, the ECM can be viewed as a reservoir to draw from for the development of new more efficacious therapies to treat angiogenesis-dependent pathologies.
引用
收藏
页数:26
相关论文
共 249 条
[21]   Cutting edge:: High molecular weight hyaluronan promotes the suppressive effects of CD4+CD25+ regulatory T cells [J].
Bollyky, Paul L. ;
Lord, James D. ;
Masewicz, Susan A. ;
Evanko, Stephen P. ;
Buckner, Jane H. ;
Wight, Thomas N. ;
Nepom, Gerald T. .
JOURNAL OF IMMUNOLOGY, 2007, 179 (02) :744-747
[22]   Matrix metalloproteinase-9 mediates post-hypoxic vascular pruning of cerebral blood vessels by degrading laminin and claudin-5 [J].
Boroujerdi, Amin ;
Welser-Alves, Jennifer V. ;
Milner, Richard .
ANGIOGENESIS, 2015, 18 (03) :255-264
[23]   Multiple-interactions among EMILIN1 and EMILIN2 N- and C-terminal domains [J].
Bot, Simonetta ;
Andreuzzi, Eva ;
Capuano, Alessandra ;
Schiavinato, Alvise ;
Colombatti, Alfonso ;
Doliana, Roberto .
MATRIX BIOLOGY, 2015, 41 :44-55
[24]   Overlapping, complementary and site-specific expression pattern of genes of the EMILIN/Multimerin family [J].
Braghetta, P ;
Ferrari, A ;
de Gemmis, P ;
Zanetti, M ;
Volpin, D ;
Bonaldo, P ;
Bressan, GM .
MATRIX BIOLOGY, 2004, 22 (07) :549-556
[25]   Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320 [J].
Bronisz, A. ;
Godlewski, J. ;
Wallace, J. A. ;
Merchant, A. S. ;
Nowicki, M. O. ;
Mathsyaraja, H. ;
Srinivasan, R. ;
Trimboli, A. J. ;
Martin, C. K. ;
Li, F. ;
Yu, L. ;
Fernandez, S. A. ;
Pecot, T. ;
Rosol, T. J. ;
Cory, S. ;
Hallett, M. ;
Park, M. ;
Piper, M. G. ;
Marsh, C. B. ;
Yee, L. D. ;
Jimenez, R. E. ;
Nuovo, G. ;
Lawler, S. E. ;
Chiocca, E. A. ;
Leone, G. ;
Ostrowski, M. C. .
NATURE CELL BIOLOGY, 2012, 14 (02) :159-167
[26]   Decorin causes autophagy in endothelial cells via Peg3 [J].
Buraschi, Simone ;
Neill, Thomas ;
Goyal, Atul ;
Poluzzi, Chiara ;
Smythies, James ;
Owens, Rick T. ;
Schaefer, Liliana ;
Torres, Annabel ;
Iozzo, Renato V. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (28) :E2582-E2591
[27]  
Butler G.S., 2016, MATRIX BIOL
[28]   Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion [J].
Carlos Rodriguez-Manzaneque, Juan ;
Carpizo, Darren ;
del Carmen Plaza-Calonge, Maria ;
Xavier Torres-Collado, Antoni ;
Thai, Shelley N. -M. ;
Simons, Michael ;
Horowitz, Arie ;
Iruela-Arispe, M. Luisa .
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2009, 41 (04) :800-810
[29]   Angiogenesis in health and disease [J].
Carmeliet, P .
NATURE MEDICINE, 2003, 9 (06) :653-660
[30]   Corneal neovascularization [J].
Chang, Jin-Hong ;
Gabison, Eric E. ;
Kato, Takuji ;
Azar, Dimitri T. .
CURRENT OPINION IN OPHTHALMOLOGY, 2001, 12 (04) :242-249