Association of LRRFIP1 gene polymorphisms with susceptibility to ischemic stroke in a Chinese population

Previous studies showed that leucine-rich repeat (in FLII) interacting protein 1 (LRRFIP1) was proposed as one regulator of the toll-like receptor (TLR) pathway signaling. The activation of LRRFIP1 protein may regulate TLR pathway signaling culminating in the production of a range of inflammatory markers, and its gene expression was influenced by a functional polymorphism in the exon region. The genetic basis of the ischemic stroke has now been largely determined, so the aim of the study was to examine the role of LRRFIP1 genetic variants in the ischemic stroke (IS) risks in a Chinese population. We conducted a case-control study with 239 IS patients and 240 controls. SNP rs3769053 of LRRFIP1 gene was analyzed for association with risk of IS in Han population. The distributions of genotypes in LRRFIP1 gene were slightly different between IS groups and health controls. And then we evaluated the association between LRRFIP1 gene (rs3769053) polymorphisms and IS with multivariate logistic regression. We found that neither TC (OR=1.353, 95% CI: 0.457-4.008, P=0. 585) nor TT (OR=1.309, 95% CI: 0.850-2.016, P=0.221) genotype was significantly associated with the risk of IS. In summary, our study reveals that the LRRFIP1 gene polymorphism (C -> T) may not be a risk factor for the development of IS in Chinese Han population.