Guided Tissue Regeneration in Heart Valve Replacement: From Preclinical Research to First-in-Human Trials

被引:27
作者
Iop, L. [1 ]
Gerosa, G. [1 ]
机构
[1] Univ Hosp Padua, Dept Cardiac Thorac & Vasc Sci, I-35128 Padua, Italy
关键词
OUTFLOW TRACT RECONSTRUCTION; ENGINEERED PULMONARY VALVE; SODIUM DODECYL-SULFATE; PORCINE AORTIC-VALVE; EXTRACELLULAR-MATRIX; BOVINE PERICARDIUM; IMMUNE-RESPONSE; HISTOLOGICAL-EVALUATION; EARLY FAILURE; DECELLULARIZATION;
D O I
10.1155/2015/432901
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Heart valve tissue-guided regeneration aims to offer a functional and viable alternative to current prosthetic replacements. Not requiring previous cell seeding and conditioning in bioreactors, such exceptional tissue engineering approach is a very fascinating translational regenerative strategy. After in vivo implantation, decellularized heart valve scaffolds drive their same repopulation by recipient's cells for a prospective autologous-like tissue reconstruction, remodeling, and adaptation to the somatic growth of the patient. With such a viability, tissue-guided regenerated conduits can be delivered as off-the-shelf biodevices and possess all the potentialities for a long-lasting resolution of the dramatic inconvenience of heart valve diseases, both in children and in the elderly. A review on preclinical and clinical investigations of this therapeutic concept is provided with evaluation of the issues still to be well deliberated for an effective and safe in-human application.
引用
收藏
页数:13
相关论文
共 110 条
  • [1] Human semilunar cardiac valve remodeling by activated cells from fetus to adult - Implications for postnatal adaptation, pathology, and tissue engineering
    Aikawa, E
    Whittaker, P
    Farber, M
    Mendelson, K
    Padera, RF
    Aikawa, M
    Schoen, FJ
    [J]. CIRCULATION, 2006, 113 (10) : 1344 - 1352
  • [2] Arai S, 2009, J HEART VALVE DIS, V18, P439
  • [3] Heart valve development - Endothelial cell signaling and differentiation
    Armstrong, EJ
    Bischoff, J
    [J]. CIRCULATION RESEARCH, 2004, 95 (05) : 459 - 470
  • [4] The cryopreservation of composite tissues Principles and recent advancement on cryopreservation of different type of tissues
    Bakhach, Joseph
    [J]. ORGANOGENESIS, 2009, 5 (03) : 119 - 126
  • [5] Orthotopic replacement of the aortic valve with decellularized allograft in a sheep model
    Baraki, Hassina
    Tudorache, Igor
    Braun, Maike
    Hoeffler, Klaus
    Goerler, Adelheid
    Lichtenberg, Artur
    Bara, Christopher
    Calistru, Alex
    Brandes, Gudrun
    Hewicker-Trautwein, Marion
    Hilfiker, Andres
    Haverich, Axel
    Cebotari, Serghei
    [J]. BIOMATERIALS, 2009, 30 (31) : 6240 - 6246
  • [6] Cell characterization of porcine aortic valve and decellularized leaflets repopulated with aortic valve interstitial cells: The VESALIO project (Vitalitate Exornatum Succedaneum Aorticum Labore Ingenioso Obtenibitur)
    Bertipaglia, B
    Ortolani, F
    Petrelli, L
    Gerosa, G
    Spina, M
    Pauletto, P
    Casarotto, D
    Marchini, M
    Sartore, S
    [J]. ANNALS OF THORACIC SURGERY, 2003, 75 (04) : 1274 - 1282
  • [7] Bloch O, 2011, TISSUE ENG PT A, V17, P2399, DOI [10.1089/ten.tea.2011.0046, 10.1089/ten.TEA.2011.0046]
  • [8] Extracellular matrix in deoxycholic acid decellularized aortic heart valves
    Bloch, Oliver
    Erdbruegger, Wilhelm
    Voelker, Wolfgang
    Schenk, Alexander
    Posner, Steffen
    Konertz, Wolfgang
    Dohmen, Pascal M.
    [J]. MEDICAL SCIENCE MONITOR, 2012, 18 (12): : BR487 - BR492
  • [9] DAMAGE OF PORCINE AORTIC-VALVE TISSUE CAUSED BY THE SURFACTANT SODIUMDODECYLSULFATE
    BODNAR, E
    OLSEN, EGJ
    FLORIO, R
    DOBRIN, J
    [J]. THORACIC AND CARDIOVASCULAR SURGEON, 1986, 34 (02) : 82 - 85
  • [10] Bodnar E, 1988, Eur J Cardiothorac Surg, V2, P43, DOI 10.1016/1010-7940(88)90095-4