Microwave-assisted Pd-catalyzed synthesis of fused steroidal and non-steroidal pyrimidines from β-halo-α,β-unsaturated aldehydes

被引：23
作者：
Gogoi, Junali [1 ]
Gogoi, Pranjal [1 ]
Bezbaruah, Pranjal [1 ]
Boruah, Romesh C. [1 ]
机构：
[1] CSIR North East Inst Sci & Technol, Div Med Chem, Jorhat 785006, Assam, India
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 52期
关键词：
Heterosteroid; Pyrimidine; Unsaturated aldehyde; Palladium; Microwave; ONE-POT SYNTHESIS; A-RING; COMPLEXES; PYRAZOLES;
D O I：
10.1016/j.tetlet.2013.10.094
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Pd-catalyzed protocol has been developed for the synthesis of fused steroidal and non-steroidal pyrimidines from beta-halo-alpha,beta-unsaturated aldehydes under microwave irradiation. The beta-halo-alpha,beta-unsaturated aldehydes are synthesized from corresponding ketones using Vilsmeier formylation reaction. This synthetic protocol is utilized to synthesize some more novel steroidal pyrimidine derivatives and are currently being evaluated for their biological activities. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7136 / 7139
页数：4
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