Liquid Biopsy for Cancer: Circulating Tumor Cells, Circulating Free DNA or Exosomes?

被引：182
|
作者：
Zhang, Wei [1 ,2 ]
Xia, Wenjie [1 ,3 ]
Lv, Zhengye [3 ]
Xin, Yin [3 ]
Ni, Chao [1 ,3 ]
Yang, Liu [1 ]
机构：
[1] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Key Lab Tumor Mol Diag & Individual Med Zhejiang, Hangzhou, Zhejiang, Peoples R China
[2] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Dept Endocrinol, Hangzhou, Zhejiang, Peoples R China
[3] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Dept Gen Surg, Hangzhou, Zhejiang, Peoples R China
来源：
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2017年 / 41卷 / 02期
关键词：
Liquid biopsy; Circulating tumor cells; Circulating free DNA; Exosomes; METASTATIC BREAST-CANCER; RADIATION-INDUCED CANCER; K-RAS MUTATIONS; LUNG-CANCER; COLORECTAL-CANCER; PANCREATIC-CANCER; PROGNOSTIC VALUE; PLASMA DNA; PROSTATE-CANCER; EARLY-DIAGNOSIS;
D O I：
10.1159/000458736
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Precision medicine and personalized medicine are based on the development of biomarkers, and liquid biopsy has been reported to be able to detect biomarkers that carry information on tumor development and progression. Compared with traditional `solid biopsy', which cannot always be performed to determine tumor dynamics, liquid biopsy has notable advantages in that it is a noninvasive modality that can provide diagnostic and prognostic information prior to treatment, during treatment and during progression. In this review, we describe the source, characteristics, technology for detection and current situation of circulating tumor cells, circulating free DNA and exosomes used for diagnosis, recurrence monitoring, prognosis assessment and medication planning. (C) 2017 The Author(s) Published by S. Karger AG, Basel
引用
收藏
页码：755 / 768
页数：14
相关论文
共 50 条
  • [41] Circulating Tumor Cells and Cell-free Nucleic Acids as Biomarkers in Colorectal Cancer
    Pourali, Ghazaleh
    Khalili-Tanha, Ghazaleh
    Nazari, Elham
    Maftooh, Mina
    Nassiri, Mohammadreza
    Hassanian, Seyed Mahdi
    Mobarhan, Majid Ghayour
    Khazaei, Majid
    Ferns, Gordon
    Avan, Amir
    CURRENT PHARMACEUTICAL DESIGN, 2023, 29 (10) : 748 - 765
  • [42] Circulating tumor DNA as a liquid biopsy target for detection of pancreatic cancer
    Erina Takai
    Shinichi Yachida
    World Journal of Gastroenterology, 2016, (38) : 8480 - 8488
  • [43] Dual Biomarker Strategies for Liquid Biopsy: Integrating Circulating Tumor Cells and Circulating Tumor DNA for Enhanced Tumor Monitoring
    Moon, Ga Young
    Dalkiran, Basak
    Park, Hyun Sung
    Shin, Dongjun
    Son, Chaeyeon
    Choi, Jung Hyun
    Bang, Seha
    Lee, Hosu
    Doh, Il
    Kim, Dong Hyung
    Jeong, Woo-jin
    Bu, Jiyoon
    BIOSENSORS-BASEL, 2025, 15 (02):
  • [44] The Emerging Role of "Liquid Biopsies," Circulating Tumor Cells, and Circulating Cell-Free Tumor DNA in Lung Cancer Diagnosis and Identification of Resistance Mutations
    Esposito, Angela
    Criscitiello, Carmen
    Trapani, Dario
    Curigliano, Giuseppe
    CURRENT ONCOLOGY REPORTS, 2017, 19 (01)
  • [45] Liquid biopsy of circulating tumor DNA and biosensor applications
    Li, Xuanying
    Ye, Mengsha
    Zhang, Weiying
    Tan, Duo
    Jaffrezic-Renault, Nicole
    Yang, Xu
    Guo, Zhenzhong
    BIOSENSORS & BIOELECTRONICS, 2019, 126 : 596 - 607
  • [46] Circulating tumor cells in pancreatic cancer: more than liquid biopsy
    Li, Zeru
    Qin, Cheng
    Zhao, Bangbo
    Li, Tianyu
    Zhao, Yutong
    Zhang, Xiangyu
    Wang, Weibin
    THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2024, 16
  • [47] Clinical applications of liquid biopsy as prognostic and predictive biomarkers in hepatocellular carcinoma: circulating tumor cells and circulating tumor DNA
    Jie Li
    Xu Han
    Xiaona Yu
    Zongzhen Xu
    Guangsheng Yang
    Bingqi Liu
    Peng Xiu
    Journal of Experimental & Clinical Cancer Research, 37
  • [48] The current status and clinical value of circulating tumor cells and circulating cell-free tumor DNA in bladder cancer
    Riethdorf, Sabine
    Soave, Armin
    Rink, Michael
    TRANSLATIONAL ANDROLOGY AND UROLOGY, 2017, 6 (06) : 1090 - 1110
  • [49] Blood-Based Analyses of Cancer: Circulating Tumor Cells and Circulating Tumor DNA
    Haber, Daniel A.
    Velculescu, Victor E.
    CANCER DISCOVERY, 2014, 4 (06) : 650 - 661
  • [50] Parallel Evaluation of Circulating Tumor DNA and Circulating Tumor Cells in Metastatic Colorectal Cancer
    Germano, Giovanni
    Mauri, Gianluca
    Siravegna, Giulia
    Dive, Caroline
    Pierce, Jackie
    Di Nicolantonio, Federica
    D'Incalci, Maurizio
    Bardelli, Alberto
    Siena, Salvatore
    Sartore-Bianchi, Andrea
    CLINICAL COLORECTAL CANCER, 2018, 17 (01) : 80 - 83
12345