Liquid Biopsy for Cancer: Circulating Tumor Cells, Circulating Free DNA or Exosomes?

被引：182
|
作者：
Zhang, Wei [1 ,2 ]
Xia, Wenjie [1 ,3 ]
Lv, Zhengye [3 ]
Xin, Yin [3 ]
Ni, Chao [1 ,3 ]
Yang, Liu [1 ]
机构：
[1] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Key Lab Tumor Mol Diag & Individual Med Zhejiang, Hangzhou, Zhejiang, Peoples R China
[2] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Dept Endocrinol, Hangzhou, Zhejiang, Peoples R China
[3] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Dept Gen Surg, Hangzhou, Zhejiang, Peoples R China
来源：
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2017年 / 41卷 / 02期
关键词：
Liquid biopsy; Circulating tumor cells; Circulating free DNA; Exosomes; METASTATIC BREAST-CANCER; RADIATION-INDUCED CANCER; K-RAS MUTATIONS; LUNG-CANCER; COLORECTAL-CANCER; PANCREATIC-CANCER; PROGNOSTIC VALUE; PLASMA DNA; PROSTATE-CANCER; EARLY-DIAGNOSIS;
D O I：
10.1159/000458736
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Precision medicine and personalized medicine are based on the development of biomarkers, and liquid biopsy has been reported to be able to detect biomarkers that carry information on tumor development and progression. Compared with traditional `solid biopsy', which cannot always be performed to determine tumor dynamics, liquid biopsy has notable advantages in that it is a noninvasive modality that can provide diagnostic and prognostic information prior to treatment, during treatment and during progression. In this review, we describe the source, characteristics, technology for detection and current situation of circulating tumor cells, circulating free DNA and exosomes used for diagnosis, recurrence monitoring, prognosis assessment and medication planning. (C) 2017 The Author(s) Published by S. Karger AG, Basel
引用
收藏
页码：755 / 768
页数：14
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