Liquid Biopsy for Cancer: Circulating Tumor Cells, Circulating Free DNA or Exosomes?

被引：185

作者：

Zhang, Wei ^{[1
,2
]}

Xia, Wenjie ^{[1
,3
]}

Lv, Zhengye ^{[3
]}

Xin, Yin ^{[3
]}

Ni, Chao ^{[1
,3
]}

Yang, Liu ^{[1
]}

机构：

[1] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Key Lab Tumor Mol Diag & Individual Med Zhejiang, Hangzhou, Zhejiang, Peoples R China

[2] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Dept Endocrinol, Hangzhou, Zhejiang, Peoples R China

[3] Hangzhou Med Coll, Peoples Hosp, Zhejiang Prov Peoples Hosp, Dept Gen Surg, Hangzhou, Zhejiang, Peoples R China

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2017年 / 41卷 / 02期

关键词：

Liquid biopsy; Circulating tumor cells; Circulating free DNA; Exosomes; METASTATIC BREAST-CANCER; RADIATION-INDUCED CANCER; K-RAS MUTATIONS; LUNG-CANCER; COLORECTAL-CANCER; PANCREATIC-CANCER; PROGNOSTIC VALUE; PLASMA DNA; PROSTATE-CANCER; EARLY-DIAGNOSIS;

D O I：

10.1159/000458736

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Precision medicine and personalized medicine are based on the development of biomarkers, and liquid biopsy has been reported to be able to detect biomarkers that carry information on tumor development and progression. Compared with traditional `solid biopsy', which cannot always be performed to determine tumor dynamics, liquid biopsy has notable advantages in that it is a noninvasive modality that can provide diagnostic and prognostic information prior to treatment, during treatment and during progression. In this review, we describe the source, characteristics, technology for detection and current situation of circulating tumor cells, circulating free DNA and exosomes used for diagnosis, recurrence monitoring, prognosis assessment and medication planning. (C) 2017 The Author(s) Published by S. Karger AG, Basel

引用

页码：755 / 768

页数：14

共 108 条

[1] Utility of serum DNA and pyrosequencing for the detection of EGFR mutations in non-small cell lung cancer [J].

Akca, Hakan ;

Demiray, Aydin ;

Yaren, Arzu ;

Bir, Ferda ;

Koseler, Aylin ;

Iwakawa, Reika ;

Bagci, Gulseren ;

Yokota, Jun .

CANCER GENETICS, 2013, 206 (03) :73-80

[2] OPINION Challenges in circulating tumour cell research [J].

Alix-Panabieres, Catherine ;

Pantel, Klaus .

NATURE REVIEWS CANCER, 2014, 14 (09) :623-631

[3]

ANKER P, 1975, CANCER RES, V35, P2375

[4]

[Anonymous], 2014, J NATL CANC I

[5] Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies [J].

Bettegowda, Chetan ;

Sausen, Mark ;

Leary, Rebecca J. ;

Kinde, Isaac ;

Wang, Yuxuan ;

Agrawal, Nishant ;

Bartlett, Bjarne R. ;

Wang, Hao ;

Luber, Brandon ;

Alani, Rhoda M. ;

Antonarakis, Emmanuel S. ;

Azad, Nilofer S. ;

Bardelli, Alberto ;

Brem, Henry ;

Cameron, John L. ;

Lee, Clarence C. ;

Fecher, Leslie A. ;

Gallia, Gary L. ;

Gibbs, Peter ;

Le, Dung ;

Giuntoli, Robert L. ;

Goggins, Michael ;

Hogarty, Michael D. ;

Holdhoff, Matthias ;

Hong, Seung-Mo ;

Jiao, Yuchen ;

Juhl, Hartmut H. ;

Kim, Jenny J. ;

Siravegna, Giulia ;

Laheru, Daniel A. ;

Lauricella, Calogero ;

Lim, Michael ;

Lipson, Evan J. ;

Marie, Suely Kazue Nagahashi ;

Netto, George J. ;

Oliner, Kelly S. ;

Olivi, Alessandro ;

Olsson, Louise ;

Riggins, Gregory J. ;

Sartore-Bianchi, Andrea ;

Schmidt, Kerstin ;

Shih, Ie-Ming ;

Oba-Shinjo, Sueli Mieko ;

Siena, Salvatore ;

Theodorescu, Dan ;

Tie, Jeanne ;

Harkins, Timothy T. ;

Veronese, Silvio ;

Wang, Tian-Li ;

Weingart, Jon D. .

SCIENCE TRANSLATIONAL MEDICINE, 2014, 6 (224)

[6] Patient-centric trials for therapeutic development in precision oncology [J].

Biankin, Andrew V. ;

Piantadosi, Steven ;

Hollingsworth, Simon J. .

NATURE, 2015, 526 (7573) :361-370

[7] The identification of KRAS mutations at codon 12 in plasma DNA is not a prognostic factor in advanced non-small cell lung cancer patients [J].

Camps, Carlos ;

Jantus-Lewintre, Eloisa ;

Cabrera, Andrea ;

Blasco, Ana ;

Sanmartin, Elena ;

Gallach, Sandra ;

Caballero, Cristina ;

del Pozo, Nieves ;

Rosell, Rafael ;

Guijarro, Ricardo ;

Sirera, Rafael .

LUNG CANCER, 2011, 72 (03) :365-369

[8] K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma:: Diagnostic utility and prognostic significance [J].

Castells, A ;

Puig, P ;

Móra, J ;

Boadas, J ;

Boix, L ;

Urgell, E ;

Solé, M ;

Capellà, G ;

Lluis, F ;

Fernández-Cruz, L ;

Navarro, S ;

Farré, A .

JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (02) :578-584

[9] Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing [J].

Chan, K. C. Allen ;

Jiang, Peiyong ;

Zheng, Yama W. L. ;

Liao, Gary J. W. ;

Sun, Hao ;

Wong, John ;

Siu, Shing Shun N. ;

Chan, Wing C. ;

Chan, Stephen L. ;

Chan, Anthony T. C. ;

Lai, Paul B. S. ;

Chiu, Rossa W. K. ;

Lo, Y. M. D. .

CLINICAL CHEMISTRY, 2013, 59 (01) :211-224

[10] Outcome of patients with ductal carcinoma in situ untreated after diagnostic biopsy - Results from the Nurses' Health Study [J].

Collins, LC ;

Tamimi, RM ;

Baer, HJ ;

Connolly, JL ;

Colditz, GA ;

Schnitt, SJ .

CANCER, 2005, 103 (09) :1778-1784

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